<\/p>\n\n\n\n
Ekz\u00e9m<\/strong> \u2013 je z\u00e1palov\u00e9 ochorenie ko\u017ee prejavuj\u00face sa svrbiv\u00fdmi, \u010derven\u00fdmi a such\u00fdmi f\u013eakmi na ko\u017ei. Naj\u010dastej\u0161ie sa vyskytuje u \u013eud\u00ed, ktor\u00ed maj\u00fa ve\u013ea alergick\u00fdch reakci\u00ed. V z\u00e1sade je to reakcia ko\u017ee na ak\u00e9ko\u013evek vonkaj\u0161ie dr\u00e1\u017edidl\u00e1, ktor\u00e9 ved\u00fa k ekz\u00e9mu.<\/p>\n\n\n\n Priazniv\u00e9 \u00fa\u010dinky melitt\u00ednu na atopick\u00fa dermatit\u00eddu vyvolan\u00fa ovalbum\u00ednom u my\u0161\u00ed<\/strong><\/p>\n\n\n\n \u00davod Dokonca aj po dlhej introspekcii AD, mechanizmus jej v\u00fdvoja e\u0161te nebol jasne pochopen\u00fd. V tomto pr\u00edpade v\u0161ak existuj\u00fa dve r\u00f4zne hypot\u00e9zy. Jedna uv\u00e1dza, \u017ee prim\u00e1rne poruchy, ktor\u00e9 u\u017e spo\u010d\u00edvaj\u00fa v imunologickej poruche, indukuj\u00fa IgE sprostredkovan\u00fa senzibiliz\u00e1ciu prostredn\u00edctvom dysfunkcie epiderm\u00e1lnej bari\u00e9ry v d\u00f4sledku lok\u00e1lneho z\u00e1palu. Druh\u00fd uv\u00e1dza, \u017ee vn\u00fatorn\u00fd defekt pr\u00edtomn\u00fd v epiteli\u00e1lnych bunk\u00e1ch vedie k dysfunkcii epiderm\u00e1lnej bari\u00e9ry a imunologick\u00e9 aspekty vznikaj\u00fa v d\u00f4sledku dysfunkcie bari\u00e9ry.<\/p>\n\n\n\n Obe vy\u0161\u0161ie uveden\u00e9 hypot\u00e9zy uv\u00e1dzaj\u00fa nejak\u00fd druh defektu imunitn\u00e9ho syst\u00e9mu a epiderm\u00e1lnej bari\u00e9ry; d\u00e1 sa poveda\u0165, \u017ee funkcia ko\u017enej bari\u00e9ry a imunitn\u00fd syst\u00e9m spolu \u00fazko spolupracuj\u00fa. Vo svetle r\u00f4znych klinick\u00fdch \u0161t\u00fadi\u00ed m\u00f4\u017ee terapia v\u010del\u00edm jedom pom\u00f4c\u0165 pri zacielen\u00ed a zlep\u0161en\u00ed imunitnej funkcie a epiderm\u00e1lnej bari\u00e9ry s\u00fa\u010dasne.<\/p>\n\n\n\n Met\u00f3da a v\u00fdsledky Farbenie H a E sa uskuto\u010dnilo na stanovenie z\u00e1palovej infiltr\u00e1cie a hr\u00fabky dermy a epidermis. Z tohto d\u00f4vodu bolo vybran\u00fdch 10 n\u00e1hodn\u00fdch pol\u00ed. Hr\u00fabka sa merala kolmo a line\u00e1rne na ka\u017ed\u00fa vzorku ko\u017ee. Zistilo sa, \u017ee stimul\u00e1cia OVA zosilnila z\u00e1palov\u00fa infiltr\u00e1ciu a sp\u00f4sobila zhrubnutie ko\u017ee my\u0161i. Zatia\u013e \u010do hr\u00fabka ko\u017ee v skupine indukovanej melit\u00ednom bola dos\u0165 tenk\u00e1 ako v skupine OVA.<\/p>\n\n\n\n Infiltr\u00e1cia imunitn\u00fdch buniek, ako s\u00fa monocyty, dendritick\u00e9 bunky, CD4+T pomocn\u00e9 bunky a makrof\u00e1gy, nazna\u010duje v\u00fdznamn\u00fa histopatologick\u00fa zmenu v AD. Antig\u00e9n makrof\u00e1gu-1 naz\u00fdvan\u00fd aj CD11b, expresia sa na\u0161la na povrchu r\u00f4znych leukocytov, ako s\u00fa makrof\u00e1gy, granulocyty a monocyty. Potvrdilo sa, \u017ee OVA-indukovan\u00e1 infiltr\u00e1cia imunitn\u00fdch buniek a priniesla \u00fa\u010dinok melit\u00ednu prostredn\u00edctvom imunohistochemick\u00e9ho farbenia CD11b a CD4. Expresia CD11b a CD4 v hornej \u010dasti ko\u017ee bola zv\u00fd\u0161en\u00e1 v skupine OVA v porovnan\u00ed so skupinou NC. OVA tie\u017e indukovala expresie CD11B a CD4, ktor\u00e9 boli zn\u00ed\u017een\u00e9 o 100 \u00b5k\/kg-1 v skupine s melit\u00ednom v porovnan\u00ed so skupinou s OVA.<\/p>\n\n\n\n V\u00fdsledok Zdroj:\u00a0<\/strong>\u200b<\/a>Beneficial effects of melittin on ovalbumin-induced atopic dermatitis in mouse<\/a><\/p>\n\n\n\n \u010eal\u0161ie \u010d\u00edtanie:\u200b<\/strong> Ekz\u00e9m \u2013 je z\u00e1palov\u00e9 ochorenie ko\u017ee prejavuj\u00face sa svrbiv\u00fdmi, \u010derven\u00fdmi a such\u00fdmi f\u013eakmi na ko\u017ei. Naj\u010dastej\u0161ie sa vyskytuje u \u013eud\u00ed, ktor\u00ed maj\u00fa ve\u013ea alergick\u00fdch reakci\u00ed. V z\u00e1sade je to reakcia ko\u017ee na ak\u00e9ko\u013evek vonkaj\u0161ie dr\u00e1\u017edidl\u00e1, ktor\u00e9 ved\u00fa k ekz\u00e9mu. Priazniv\u00e9 \u00fa\u010dinky melitt\u00ednu na atopick\u00fa dermatit\u00eddu vyvolan\u00fa ovalbum\u00ednom u my\u0161\u00ed \u00davodAD (atopick\u00e1 dermatit\u00edda) je definovan\u00e1 ako […]<\/p>\n","protected":false},"author":1,"featured_media":112,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"ngg_post_thumbnail":0},"categories":[7],"tags":[],"yoast_head":"\n
AD (atopick\u00e1 dermatit\u00edda) je definovan\u00e1 ako z\u00e1palov\u00e9 ko\u017en\u00e9 ochorenie, ktor\u00e9 je charakterizovan\u00e9 recidivuj\u00facimi ekzemat\u00f3znymi l\u00e9ziami a intenz\u00edvnym svrben\u00edm. Toto ochorenie zvy\u0161uje riziko du\u0161evn\u00fdch por\u00fach, in\u00fdch ochoren\u00ed s\u00favisiacich s imunitn\u00fdm syst\u00e9mom, alergickej rinit\u00eddy, astmy a potravinovej alergie. AD vznik\u00e1 v d\u00f4sledku ch\u00fdb imunoglobul\u00ednu E a senzibiliz\u00e1cie sprostredkovanej epiderm\u00e1lnou bari\u00e9rou na r\u00f4zne environment\u00e1lne alerg\u00e9ny. Zatia\u013e \u010do porucha imunity vznik\u00e1 v d\u00f4sledku nerovnov\u00e1hy vytvorenej smerom k odpovedi T-helper-2.<\/p>\n\n\n\n
AD bola indukovan\u00e1 u vybran\u00e9ho modelu my\u0161\u00ed. Zistilo sa, \u017ee po podan\u00ed AD sa ich stav ko\u017ee zhor\u0161il, \u010do vedie k exkori\u00e1cii, eryt\u00e9mu a ed\u00e9mu. Tieto sympt\u00f3my boli kontrolovan\u00e9 a odstr\u00e1nen\u00e9, ke\u010f vybran\u00e1 skupina dostala terapiu melit\u00ednom. Melitt\u00edn je integr\u00e1lnou terapeutickou zlo\u017ekou v\u010delieho jedu.<\/p>\n\n\n\n
D\u00e1 sa poveda\u0165, \u017ee OVA m\u00f4\u017ee hra\u0165 v\u00fdznamn\u00fa \u00falohu pri obmedzovan\u00ed sympt\u00f3mov typu AD, ako je zhrubnutie dermis a epidermis, nedostatok filagr\u00ednu, z\u00e1palov\u00e1 infiltr\u00e1cia, zv\u00fd\u0161en\u00e9 z\u00e1palov\u00e9 medi\u00e1tory a prehnan\u00e9 s\u00e9rov\u00e9 \u200b\u200bIgE. T\u00e1to \u0161t\u00fadia sl\u00fa\u017ei ako d\u00f4kaz, \u017ee melit\u00edn pri kontrolovanej koncentr\u00e1cii m\u00f4\u017ee vies\u0165 k protiz\u00e1palov\u00fdm \u00fa\u010dinkom na AD vyvolan\u00fa OVA.<\/p>\n\n\n\n
Bee Venom\u00a0Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions…<\/a>
Bee venom\u00a0acupuncture alleviates trimellitic anhydride-induced atopic dermatitis-like skin lesions in mice<\/a>
Bee venom ameliorates compound 48\/80-induced atopic dermatitis-related symptoms<\/a>
\u200b<\/a>Bee venom\u00a0ameliorates compound 48\/80-induced atopic dermatitis-related symptoms<\/a>
Therapeutic effects of\u00a0bee venom\u00a0and its major component, melittin, on atopic dermatitis\u00a0in vivo and\u00a0in vitro<\/a>
Therapeutic effects of\u00a0bee venom\u00a0on experimental atopic dermatitis<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"