{"id":194,"date":"2022-07-20T08:27:16","date_gmt":"2022-07-20T06:27:16","guid":{"rendered":"http:\/\/apitoxin.sk\/?p=194"},"modified":"2022-07-20T08:27:17","modified_gmt":"2022-07-20T06:27:17","slug":"liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia","status":"publish","type":"post","link":"http:\/\/d.r5.wbsprt.com\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/","title":{"rendered":"Lie\u010dba v\u010del\u00edm jedom na syst\u00e9mov\u00fa skler\u00f3zu \/sklerodermia\/"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>\u010co je systematick\u00e1 skler\u00f3za?<br>M\u00f4\u017eeme ho definova\u0165 ako zriedkav\u00e9, ale chronick\u00e9 ochorenie, sp\u00f4soben\u00e9 z nezn\u00e1mych pr\u00ed\u010din, ktor\u00e9 je charakterizovan\u00e9 cievnymi abnormalitami a dif\u00faznou fibr\u00f3zou vn\u00fatorn\u00fdch org\u00e1nov, k\u013abov a ko\u017ee. Jeho diagn\u00f3za m\u00f4\u017ee by\u0165 stanoven\u00e1 iba na klinickej \u00farovni pomocou laborat\u00f3rnych testov. Dodr\u017eiavanie \u0161pecifickej lie\u010dby po stanoven\u00ed diagn\u00f3zy je n\u00e1ro\u010dn\u00e9, preto\u017ee ka\u017ed\u00fd konven\u010dn\u00fd liek m\u00e1 svoje komplik\u00e1cie.<br>\u200b<br>Ak\u00e9 s\u00fa typy systematickej skler\u00f3zy?<br>Je klasifikovan\u00fd do troch r\u00f4znych kateg\u00f3ri\u00ed:<\/p>\n\n\n\n<p>1.) Obmedzen\u00e1 systematick\u00e1 skler\u00f3za \u2013 je zn\u00e1ma aj ako syndr\u00f3m CREST. Pri tomto type SSc u subjektov doch\u00e1dza k nap\u00ednaniu ko\u017ee na tv\u00e1ri a v bl\u00edzkosti kolien a lak\u0165ov. Pacient m\u00f4\u017ee ma\u0165 aj gastroezofage\u00e1lny reflux. Postupuje pomaly, ale nesk\u00f4r sa m\u00f4\u017ee skomplikova\u0165 v d\u00f4sledku p\u013e\u00facnej hypertenzie.<\/p>\n\n\n\n<p>2.) Generalizovan\u00e1 systematick\u00e1 skler\u00f3za \u2013 u pacientov sa vyvin\u00fa GI komplik\u00e1cie a Raynaudov fenom\u00e9n spolu s dif\u00faznym pohybom ko\u017ee. Ide o r\u00fdchlo progreduj\u00face ochorenie, ktor\u00e9 m\u00f4\u017ee nesk\u00f4r skomplikova\u0165 sklerodermiu a interstici\u00e1lnu chorobu p\u013e\u00fac.<\/p>\n\n\n\n<p>3.) Systematick\u00e1 skler\u00f3za sine sklerodermia \u2013 nevedie k \u017eiadnym pr\u00edznakom nap\u00ednania ko\u017ee, ale pacienti poci\u0165uj\u00fa viscer\u00e1lny prejav tohto ochorenia a systematick\u00e9 protil\u00e1tky proti skler\u00f3ze.<\/p>\n\n\n\n<p>Ak\u00e9 s\u00fa pr\u00edznaky systematickej skler\u00f3zy?<br>R\u00f4zne sympt\u00f3my alebo pr\u00edznaky tohto ochorenia sa za\u010d\u00ednaj\u00fa objavova\u0165 po epiz\u00f3dach Raynaudovho fenom\u00e9nu \u2013 vyv\u00edja sa nieko\u013eko t\u00fd\u017ed\u0148ov pred fibr\u00f3zou. Raynaudov jav sp\u00f4sobuje, \u017ee prsty na ruk\u00e1ch a noh\u00e1ch pacienta zmodraj\u00fa alebo zbelej\u00fa v reakcii na stres alebo zmeny teploty. Je to sp\u00f4soben\u00e9 t\u00fdm, \u017ee s\u00fa po\u0161koden\u00e9 drobn\u00e9 krvn\u00e9 cievy a je ovplyvnen\u00e1 ich schopnos\u0165 pren\u00e1\u0161a\u0165 krv do r\u00f4znych kon\u010dat\u00edn. Medzi \u010fal\u0161ie pr\u00edznaky patria:<br>&#8211; Opuchnut\u00e9 a opuchnut\u00e9 ruky alebo nohy<br>&#8211; Zhrubnutie a spevnenie poko\u017eky (najsk\u00f4r od prstov)<br>&#8211; Vredy na prstoch<br>&#8211; Bolestiv\u00e9 hr\u010dky priamo pod ko\u017eou<br>&#8211; Zhluky krvn\u00fdch ciev pod ko\u017eou, ktor\u00e9 sa zdaj\u00fa by\u0165 zv\u00e4\u010d\u0161en\u00e9<br>&#8211; Boles\u0165, necitlivos\u0165 a stuhnutos\u0165 v r\u00f4znych k\u013aboch<br>&#8211; \u010cerven\u00e9 \u0161kvrny na hrudi a tv\u00e1ri<br>&#8211; Svalov\u00e1 slabos\u0165<\/p>\n\n\n\n<p>Ako p\u00f4sob\u00ed systematick\u00e1 skler\u00f3za vn\u00fatorne?<br>SSc vedie k fibr\u00f3ze, ktor\u00e1 m\u00f4\u017ee v\u00e1\u017ene po\u0161kodi\u0165 aj vn\u00fatorn\u00e9 org\u00e1ny a v niektor\u00fdch pr\u00edpadoch m\u00f4\u017ee d\u00f4js\u0165 a\u017e k \u00fapln\u00e9mu zlyhaniu alebo po\u0161kodeniu postihnut\u00fdch org\u00e1nov. Fibr\u00f3za m\u00f4\u017ee \u013eahko postihn\u00fa\u0165 obli\u010dky, p\u013e\u00faca, srdce a pa\u017eer\u00e1k. Poruchy vn\u00fatorn\u00fdch org\u00e1nov m\u00f4\u017eu tie\u017e vies\u0165 k hna\u010dke, d\u00fdchavi\u010dnosti, po\u0161kodeniu \u010drevn\u00fdch svalov, probl\u00e9mom s obli\u010dkami, hypertenzii, dysf\u00e1gii a p\u00e1leniu z\u00e1hy.<\/p>\n\n\n\n<p><strong>Akupunkt\u00fara v\u010delieho jedu pre ohrani\u010den\u00fa morfiu u pacienta so syst\u00e9movou skler\u00f3zou<\/strong><\/p>\n\n\n\n<p>\u00davod<br>SSc, ako je uveden\u00e9 vy\u0161\u0161ie, je zriedkav\u00e9 autoimunitn\u00e9 ochorenie spojivov\u00fdch tkan\u00edv, ktor\u00e9 je spojen\u00e9 s postihnut\u00edm vn\u00fatorn\u00fdch org\u00e1nov, k\u013abov a ko\u017ee. Hoci medic\u00edna pre\u0161la ve\u013ek\u00fdm v\u00fdvojom, doteraz nie je pre t\u00fato chorobu k dispoz\u00edcii \u017eiadna spr\u00e1vna lie\u010dba. V s\u00fa\u010dasnosti sa na lie\u010dbu sympt\u00f3mov SSc pou\u017e\u00edva lok\u00e1lny vitam\u00edn D, fototerapia, peror\u00e1lne steroidy a imunosupres\u00edva. Hoci terapie pom\u00e1haj\u00fa zmierni\u0165 v\u0161eobecn\u00e9 sympt\u00f3my, ka\u017ed\u00e1 lie\u010dba m\u00e1 nejak\u00e9 ved\u013eaj\u0161ie \u00fa\u010dinky, ako je boles\u0165 hlavy, svrbenie a p\u00e1lenie ko\u017ee.<\/p>\n\n\n\n<p>Pod\u013ea r\u00f4znych klinick\u00fdch \u0161t\u00fadi\u00ed sa zistilo, \u017ee alternat\u00edvne lie\u010dby m\u00f4\u017eu zmierni\u0165 sympt\u00f3my SSc. Farmakopunkt\u00fara je jedn\u00fdm z najpopul\u00e1rnej\u0161\u00edch typov akupunkt\u00farnych o\u0161etren\u00ed, ktor\u00e9 prijali re\u017eimy tradi\u010dnej \u010d\u00ednskej a k\u00f3rejskej medic\u00edny. Po\u010das tejto lie\u010dby s\u00fa akupunkt\u00farne body stimulovan\u00e9 injekciou r\u00f4znych rastlinn\u00fdch liekov. Spomedzi pou\u017e\u00edvan\u00fdch rastlinn\u00fdch liekov mo\u017eno akupunkt\u00faru v\u010delieho jedu pova\u017eova\u0165 za najlep\u0161iu farmakopunkt\u00farnu lie\u010dbu.<\/p>\n\n\n\n<p>V\u010del\u00ed jed sa pou\u017e\u00edva u\u017e ve\u013emi dlho ako alternat\u00edvny alebo doplnkov\u00fd liek, preto\u017ee m\u00e1 siln\u00e9 antiaterosklerotick\u00e9, antifibrotick\u00e9, antinocicept\u00edvne, antiapoptotick\u00e9 a protiz\u00e1palov\u00e9 \u00fa\u010dinky.<\/p>\n\n\n\n<p>Spr\u00e1va o pr\u00edpade<br>U 64-ro\u010dn\u00e9ho pacienta s hmotnos\u0165ou okolo 45 kg bola diagnostikovan\u00e1 SSc. V\u0161etko to za\u010dalo, ke\u010f si v\u0161imla svrbenie v pravom later\u00e1lnom bedrovom hrebeni a \u017eiadne lok\u00e1lne upokojuj\u00face kr\u00e9my jej nepomohli kontrolova\u0165 svrbenie. Okrem svrbenia sa okolo prav\u00e9ho later\u00e1lneho hrebe\u0148a bedrovej kosti vyskytovali aj biele \u0161kvrny s priemerom 1 a\u017e 3 cm. Jej pr\u00edznaky boli dos\u0165 podobn\u00e9 pr\u00edznakom uhryznutia \u010dervom. Po n\u00e1v\u0161teve Gachonskej univerzity Gil Korean Medical Hospital bola jej anamn\u00e9za \u010falej odhalen\u00e1.<br>Zistilo sa, \u017ee u\u017e bola pacientkou SSc, Takayasuovej arterit\u00eddy a podst\u00fapila oper\u00e1ciu aorty. V minulosti u\u017e\u00edvala aspir\u00edn, antitusik\u00e1, steroidy a lieky proti bolesti. Ale tentoraz sa spolu s n\u00e1plas\u0165ou na podr\u00e1\u017edenie s\u0165a\u017eovala aj na chudnutie a \u00fanavu. Zistilo sa tie\u017e, \u017ee v minulosti dostala farmakopunkt\u00faru v\u010delieho jedu na lie\u010dbu chronickej bolesti ramena a nezaznamenala \u017eiadne nepriazniv\u00e9 \u00fa\u010dinky.<\/p>\n\n\n\n<p>Op\u00e4\u0165 sa teda zvolila farmakopunkt\u00fara v\u010delieho jedu. Bol podan\u00fd, ke\u010f sa po nieko\u013ek\u00fdch hodnoteniach potvrdilo, \u017ee je vhodn\u00e1 na terapiu BV. Na vykonanie tejto \u0161t\u00fadie bol pripraven\u00fd sterilizovan\u00fd roztok v\u010delieho jedu aseptick\u00fdm spracovan\u00edm 1 g su\u0161en\u00e9ho v\u010delieho jedu, ktor\u00fd bol nakoniec rozpusten\u00fd v 10 000 cm3 vody. Jaseng Herbal Medicine Dispensary poskytol roztok na farmakopunkciu v\u010delieho jedu. Akupunkt\u00fara v\u010delieho jedu bola injikovan\u00e1 subkut\u00e1nne pozd\u013a\u017e okrajov n\u00e1plast\u00ed (povrchov\u00e1 ohrani\u010den\u00e1 l\u00e9zia) pomocou met\u00f3dy plytkej obklopuj\u00facej ihly. 0,02 ml v\u010delieho jedu sa vstreklo do ka\u017ed\u00e9ho miesta pomocou inzul\u00ednovej strieka\u010dky 31 gauge do h\u013abky maxim\u00e1lne 4 mm. Zabezpe\u010dilo sa, aby celkov\u00fd vstrekovan\u00fd objem v\u010delieho jedu nepresiahol 0,2 ml. T\u00e1to lie\u010dba sa pod\u00e1vala dvakr\u00e1t t\u00fd\u017edenne po\u010das 7 dn\u00ed a nesk\u00f4r sa zn\u00ed\u017eila na jednu d\u00e1vku t\u00fd\u017edenne. Tento re\u017eim sa dodr\u017eiaval nepretr\u017eite 3 t\u00fd\u017edne.<\/p>\n\n\n\n<p>Pozorovalo sa, \u017ee po prvom o\u0161etren\u00ed sa sk\u00f3re pacientov s\u00favisiace s priemernou poruchou sp\u00e1nku a svrben\u00edm zn\u00ed\u017eilo na stupnicu 6 a\u017e 2 a 8 a\u017e 4 v tomto porad\u00ed. Sk\u00f3re bolo meran\u00e9 na NRS11 (11-bodov\u00e1 \u010d\u00edseln\u00e1 stupnica). Po tretej n\u00e1v\u0161teve bolo hl\u00e1sen\u00e9, \u017ee svrbenie sa takmer zmen\u0161ilo po 2 pravideln\u00fdch o\u0161etreniach \u2013 len ob\u010das sa znovu objavilo slab\u00e9. Sk\u00f3re nesk\u00f4r kleslo na 0 a zostalo rovnak\u00e9 a\u017e do jej piatej n\u00e1v\u0161tevy. Po jej piatej n\u00e1v\u0161teve sa zistilo, \u017ee ju u\u017e nesvrb\u00ed, a preto sa jej sp\u00e1nok zlep\u0161il. Ke\u010f svrbenie zmizlo, zlep\u0161ila sa aj jej poko\u017eka. Po 3 mesiacoch sledovania sa zistilo, \u017ee vzh\u013ead postihnutej ko\u017ee sa vr\u00e1til do norm\u00e1lu. Ke\u010f\u017ee pacient bol s terapiou v\u010del\u00edm jedom \u00faplne spokojn\u00fd, nebolo potrebn\u00e9 v lie\u010dbe pokra\u010dova\u0165. Po\u010das tohto o\u0161etrenia neboli zaznamenan\u00e9 \u017eiadne ne\u017eiaduce \u00fa\u010dinky okrem mierneho svrbenia v mieste vpichu, ktor\u00e9 trvalo len 36 hod\u00edn a potom \u00faplne vymizlo.<\/p>\n\n\n\n<p>Diskusia<br>Morphea je op\u00edsan\u00e1 ako lokalizovan\u00e1 sklerodermia, \u010do je z\u00e1palov\u00e9 ochorenie, ktor\u00e9 postihuje podko\u017en\u00e9 tkanivo a ko\u017eu a je charakterizovan\u00e9 abnorm\u00e1lnym ukladan\u00edm kolag\u00e9nu, ktor\u00e9 nakoniec vedie k fibr\u00f3ze. V porovnan\u00ed so SSc a Raynaudov\u00fdm fenom\u00e9nom v LoS ch\u00fdba viscer\u00e1lne postihnutie a typick\u00e9 protil\u00e1tky. LoS je sk\u00f4r dermatologick\u00e9 ochorenie, ale prekr\u00fdva sa s in\u00fdmi ochoreniami (v\u00e4\u010d\u0161ina z nich s\u00fa autoimunitn\u00e9 ochorenia) alebo sa vyskytuje ako sympt\u00f3m nejak\u00e9ho druhu evol\u00facie smerom k akejko\u013evek syst\u00e9movej forme. LoS a SSc s\u00fa odli\u0161n\u00e9 klinick\u00e9 entity, ale predstavuj\u00fa analogick\u00e9 histopatologick\u00e9 n\u00e1lezy. V LoS bola zisten\u00e1 pr\u00edtomnos\u0165 Raynaudovho fenom\u00e9nu alebo protil\u00e1tok.<\/p>\n\n\n\n<p>Pod\u013ea klinickej \u0161t\u00fadie vykonanej sk\u00f4r nie je mo\u017en\u00e9 vyl\u00fa\u010di\u0165 mo\u017en\u00fd v\u00fdvoj alebo koexistenciu LoS a SSc. Predch\u00e1dzaj\u00face \u0161t\u00fadie tie\u017e deklarovali, \u017ee CAM terapia podporuje fyzick\u00fa a du\u0161evn\u00fa pohodu u pacientov so SSc. Z\u00e1rove\u0148 v\u0161ak celkov\u00fd \u00fa\u010dinok t\u00fdchto terapi\u00ed na akt\u00edvnu f\u00e1zu morfea u pacientov s SSc e\u0161te nebol hl\u00e1sen\u00fd.<\/p>\n\n\n\n<p>V\u010del\u00ed jed sa sklad\u00e1 z r\u00f4znych pr\u00edrodn\u00fdch produktov, ktor\u00e9 obsahuj\u00fa prospe\u0161n\u00e9 farmaceutick\u00e9 prvky, ktor\u00e9 sa skladaj\u00fa z peptidov, enz\u00fdmov a nepeptidov\u00fdch zlo\u017eiek. Pou\u017eitie v\u010delieho jedu v niektor\u00fdch \u0161pecifick\u00fdch bodoch je zn\u00e1me ako; terapia v\u010del\u00edm jedom alebo farmakopunkt\u00fara alebo akupunkt\u00fara v\u010del\u00edm jedom v TKM. Zistilo sa, \u017ee v\u010del\u00ed jed ovplyv\u0148uje vaskul\u00e1rny endotelov\u00fd rastov\u00fd faktor, fibr\u00f3zu, imunitn\u00fa regul\u00e1ciu a protirakovinov\u00e9 \u00fa\u010dinky. \u00da\u010dinnos\u0165 v\u010delieho jedu m\u00f4\u017ee by\u0165 spojen\u00e1 s vy\u0161\u0161ie uveden\u00fdmi pr\u00ed\u010dinami morfea. Aj ke\u010f je v\u010del\u00ed jed v s\u00fa\u010dasnosti \u0161iroko pou\u017e\u00edvan\u00fd pre svoje prospe\u0161n\u00e9 vlastnosti, v niektor\u00fdch pr\u00edpadoch boli hl\u00e1sen\u00e9 aj nepriazniv\u00e9 \u00fa\u010dinky, ako je opuch a svrbenie.<\/p>\n\n\n\n<p>Na vykonanie tejto klinickej \u0161t\u00fadie bola prijat\u00e1 technika plytk\u00e9ho obklopuj\u00faceho vpichovania na zameranie ohrani\u010denej morfey, ktor\u00e1 je lokalizovan\u00e1 v podko\u017enom tkanive a ko\u017ei. Akupunkt\u00fara v\u010del\u00edm jedom sa pod\u00e1vala subkut\u00e1nne spolu s povrchov\u00fdmi ohrani\u010den\u00fdmi l\u00e9ziami. Pre ve\u013ek\u00fa n\u00e1plas\u0165 bola prijat\u00e1 technika obkolesen\u00e9ho vpichovania, zatia\u013e \u010do pre mal\u00fa n\u00e1plas\u0165 bol vybran\u00fd iba jeden bod. Je to starod\u00e1vna met\u00f3da vpichovania, ktor\u00e1 sa pou\u017e\u00edva na lie\u010dbu ko\u017en\u00fdch probl\u00e9mov zameran\u00edm sa na stred tohto bodu. \u010eal\u0161ie vpichovanie sa vykon\u00e1va na zadnej, prednej, \u013eavej a pravej strane tohto bodu, aby sa rie\u0161ili roz\u0161\u00edren\u00e9 patog\u00e9nne faktory.<\/p>\n\n\n\n<p>T\u00e1to klinick\u00e1 \u0161t\u00fadia je celkom odli\u0161n\u00e1 od ostatn\u00fdch, ke\u010f\u017ee sa zameriava na terapiu LoS v\u010del\u00edm jedom. Asoci\u00e1cia SSc a morphea je ozna\u010den\u00e1 ako zriedkav\u00fd stav. Tento pr\u00edpad predstavoval zlep\u0161enie lok\u00e1lnych ko\u017en\u00fdch sympt\u00f3mov, ktor\u00e9 s\u00fa spojen\u00e9 so svrben\u00edm a poruchou sp\u00e1nku prostredn\u00edctvom terapie v\u010del\u00edm jedom u pacienta s LoS, ktor\u00fd u\u017e mal SSc. D\u00e1 sa poveda\u0165, \u017ee terapia v\u010del\u00edm jedom m\u00f4\u017ee by\u0165 pou\u017eit\u00e1 ako alternat\u00edvna met\u00f3da lie\u010dby morfea \u2013 so syst\u00e9movou skler\u00f3zou alebo bez nej. Aj ke\u010f to vy\u017eaduje spr\u00e1vne pou\u017eitie \u2013 na dosiahnutie po\u017eadovan\u00fdch v\u00fdsledkov je potrebn\u00e9 presne dodr\u017eiava\u0165 d\u00e1vku a met\u00f3du vpichovania. Zistilo sa teda, \u017ee lok\u00e1lne ko\u017en\u00e9 sympt\u00f3my pacienta sa v\u00fdrazne zlep\u0161ili po pravidelnej lie\u010dbe na obdobie 5 mesiacov \u2013 v\u00fdsledok sa udr\u017eal a\u017e do 3-mesa\u010dn\u00e9ho pl\u00e1nu sledovania.<br>T\u00e1to pr\u00edpadov\u00e1 \u0161t\u00fadia m\u00e1 svoje obmedzenia, preto\u017ee vzorka \u0161t\u00fadie bola mal\u00e1 a neexistovala \u017eiadna kontroln\u00e1 skupina, ktor\u00e1 by vykonala porovnanie. Neuskuto\u010dnilo sa ani histopatologick\u00e9 pozorovanie a celkov\u00e9 zlep\u0161enie sa ur\u010dilo len na z\u00e1klade zlep\u0161uj\u00facich sa ko\u017en\u00fdch sympt\u00f3mov. T\u00e1to pr\u00edpadov\u00e1 \u0161t\u00fadia v\u0161ak m\u00f4\u017ee poskytn\u00fa\u0165 z\u00e1klad pre pou\u017eitie v\u010delieho jedu na lie\u010dbu ohrani\u010denej morfey pomocou SSc. \u010eal\u0161ie experimenty m\u00f4\u017eu vyu\u017ei\u0165 vizu\u00e1lnu anal\u00f3gov\u00fa stupnicu alebo NRS na presn\u00e9 meranie svrbenia.<\/p>\n\n\n\n<p>V\u00fdsledok<br>BV akupunkt\u00fara m\u00e1 potenci\u00e1l na pou\u017eitie ako \u00fa\u010dinn\u00e1 terapia pre ohrani\u010den\u00fa morfiu. Rozsiahly v\u00fdskum v bud\u00facnosti v\u0161ak mus\u00ed by\u0165 navrhnut\u00fd tak, aby vysvetlil optim\u00e1lnu modalitu terapie BV.<\/p>\n\n\n\n<p>Predlie\u010dba v\u010del\u00edm jedom m\u00e1 antinocicept\u00edvny aj protiz\u00e1palov\u00fd \u00fa\u010dinok na z\u00e1paly vyvolan\u00e9 karag\u00e9nanom<\/p>\n\n\n\n<p>Abstraktn\u00e9<br>Injekcia v\u010delieho jedu pom\u00e1ha vyvola\u0165 hyperalg\u00e9ziu a tonick\u00fa boles\u0165, ale v klinickej literat\u00fare s\u00fa dostupn\u00e9 mierne protichodn\u00e9 d\u00f4kazy, ktor\u00e9 nazna\u010duj\u00fa, \u017ee v\u010del\u00ed jed m\u00f4\u017ee ma\u0165 aj antinocicept\u00edvne a protiz\u00e1palov\u00e9 \u00fa\u010dinky na z\u00e1pal. V\u010del\u00ed jed sa pou\u017e\u00edva v r\u00f4znych orient\u00e1lnych liekoch na lie\u010dbu chronick\u00fdch z\u00e1palov\u00fdch ochoren\u00ed a na zmiernenie bolesti. T\u00e1to \u0161t\u00fadia sa uskuto\u010dnila za norm\u00e1lnych podmienok na testovanie \u00falohy v\u010delieho jedu pri ak\u00fatnej nocicepcii.<\/p>\n\n\n\n<p>Klinick\u00fd experiment bol navrhnut\u00fd tak, aby \u0161peci\u00e1lne vyhodnotil \u00fa\u010dinky predo\u0161etrenia v\u010del\u00edm jedom na tepeln\u00fa hyperalg\u00e9ziu a ak\u00fatny ed\u00e9m labky vyvolan\u00fd CR. Kvantitat\u00edvna anal\u00fdza expresie Fos miechy bola v\u00fdsledkom perif\u00e9rneho z\u00e1palu. Zistilo sa, \u017ee u norm\u00e1lnych zvierat subkut\u00e1nna injekcia v\u010delieho jedu podan\u00e1 do zadnej kon\u010datiny mierne zv\u00fd\u0161ila expresiu Fos v mieche. Toto sa uskuto\u010dnilo bez vyvolania ak\u00e9hoko\u013evek druhu detekovate\u013enej hyperalg\u00e9zie alebo nocicept\u00edvneho spr\u00e1vania.<\/p>\n\n\n\n<p>Naproti tomu predbe\u017en\u00e9 o\u0161etrenie v\u010del\u00edm jedom v d\u00e1vke 0,8 mg\/kg 30 min\u00fat pred injekciou CR viedlo k potla\u010deniu tepelnej hyperalg\u00e9zie a ed\u00e9mu labky vyvolan\u00e9mu CR. Bola tie\u017e zisten\u00e1 pozit\u00edvna korel\u00e1cia medzi expresiou Fos pozit\u00edvnych neur\u00f3nov v mieche a percentu\u00e1lnou zmenou objemu labky.<\/p>\n\n\n\n<p>Pod\u013ea t\u00fdchto v\u00fdsledkov mo\u017eno kon\u0161tatova\u0165, \u017ee lie\u010dba v\u010del\u00edm jedom m\u00e1 za n\u00e1sledok protiz\u00e1palov\u00e9 a antinocicept\u00edvne \u00fa\u010dinky v \u010cR indukovanej z\u00e1palovej bolesti. Z\u00edskan\u00e9 \u00fadaje tie\u017e nazna\u010duj\u00fa, \u017ee kontrolovan\u00e1 lie\u010dba v\u010del\u00edm jedom m\u00f4\u017ee by\u0165 prospe\u0161n\u00e1 pri lie\u010dbe ed\u00e9mu a bolesti, ktor\u00e1 vznik\u00e1 v d\u00f4sledku ak\u00e9hoko\u013evek chronick\u00e9ho z\u00e1palov\u00e9ho ochorenia.<\/p>\n\n\n\n<p>Z\u00e1ver<br>Akupunkt\u00fara v\u010del\u00edm jedom pon\u00faka vhodn\u00e9 rie\u0161enie na lie\u010dbu r\u00f4znych sympt\u00f3mov syst\u00e9movej skler\u00f3zy a jej \u010fal\u0161\u00edch prejavov. M\u00f4\u017ee sa pou\u017e\u00edva\u0165 pravidelne nieko\u013eko mesiacov, k\u00fdm pr\u00edznaky nezmizn\u00fa a najlep\u0161ie je, \u017ee; nevedie k \u017eiadnym z\u00e1va\u017en\u00fdm ne\u017eiaducim \u00fa\u010dinkom, ktor\u00e9 m\u00f4\u017eu sp\u00f4sobi\u0165 in\u00e9 konven\u010dn\u00e9 lieky. Na ur\u010denie presnej d\u00e1vky a sp\u00f4sobu pou\u017eitia akupunkt\u00fary v\u010delieho jedu, ktor\u00e9 by pomohli pri rie\u0161en\u00ed ak\u00e9hoko\u013evek \u0161pecifick\u00e9ho sympt\u00f3mu syst\u00e9movej skler\u00f3zy, s\u00fa v\u0161ak potrebn\u00e9 \u010fal\u0161ie klinick\u00e9 \u0161t\u00fadie, ktor\u00e9 s\u00fa zalo\u017een\u00e9 na obrovsk\u00fdch vzork\u00e1ch a komplexn\u00fdch hodnotiacich krit\u00e9ri\u00e1ch.<\/p>\n\n\n\n<p><strong>\u200bZdroj:<\/strong><br>1:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6310600\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bee venom acupuncture for circumscribed morphea in a patient with systemic sclerosis<\/a><br>2:<a href=\"https:\/\/www.researchgate.net\/publication\/12026516_Bee_Venom_Pretreatment_Has_Both_an_Antinociceptive_and_Anti-Inflammatory_Effect_on_Carrageenan-Induced_Inflammation\" target=\"_blank\" rel=\"noreferrer noopener\">\u00a0Bee venom has been reported to demonstrate antinociceptive and anti-inflammatory effects in experimental studies<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u010co je systematick\u00e1 skler\u00f3za?M\u00f4\u017eeme ho definova\u0165 ako zriedkav\u00e9, ale chronick\u00e9 ochorenie, sp\u00f4soben\u00e9 z nezn\u00e1mych pr\u00ed\u010din, ktor\u00e9 je charakterizovan\u00e9 cievnymi abnormalitami a dif\u00faznou fibr\u00f3zou vn\u00fatorn\u00fdch org\u00e1nov, k\u013abov a ko\u017ee. Jeho diagn\u00f3za m\u00f4\u017ee by\u0165 stanoven\u00e1 iba na klinickej \u00farovni pomocou laborat\u00f3rnych testov. Dodr\u017eiavanie \u0161pecifickej lie\u010dby po stanoven\u00ed diagn\u00f3zy je n\u00e1ro\u010dn\u00e9, preto\u017ee ka\u017ed\u00fd konven\u010dn\u00fd liek m\u00e1 svoje komplik\u00e1cie.\u200bAk\u00e9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":195,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"ngg_post_thumbnail":0},"categories":[7],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lie\u010dba v\u010del\u00edm jedom na syst\u00e9mov\u00fa skler\u00f3zu \/sklerodermia\/ - apitoxin.sk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lie\u010dba v\u010del\u00edm jedom na syst\u00e9mov\u00fa skler\u00f3zu \/sklerodermia\/ - apitoxin.sk\" \/>\n<meta property=\"og:description\" content=\"\u010co je systematick\u00e1 skler\u00f3za?M\u00f4\u017eeme ho definova\u0165 ako zriedkav\u00e9, ale chronick\u00e9 ochorenie, sp\u00f4soben\u00e9 z nezn\u00e1mych pr\u00ed\u010din, ktor\u00e9 je charakterizovan\u00e9 cievnymi abnormalitami a dif\u00faznou fibr\u00f3zou vn\u00fatorn\u00fdch org\u00e1nov, k\u013abov a ko\u017ee. Jeho diagn\u00f3za m\u00f4\u017ee by\u0165 stanoven\u00e1 iba na klinickej \u00farovni pomocou laborat\u00f3rnych testov. Dodr\u017eiavanie \u0161pecifickej lie\u010dby po stanoven\u00ed diagn\u00f3zy je n\u00e1ro\u010dn\u00e9, preto\u017ee ka\u017ed\u00fd konven\u010dn\u00fd liek m\u00e1 svoje komplik\u00e1cie.\u200bAk\u00e9 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/\" \/>\n<meta property=\"og:site_name\" content=\"apitoxin.sk\" \/>\n<meta property=\"article:published_time\" content=\"2022-07-20T06:27:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-20T06:27:17+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/apitoxin.sk\/wp-content\/uploads\/2022\/07\/systematic.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1580\" \/>\n\t<meta property=\"og:image:height\" content=\"890\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Autor\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Predpokladan\u00fd \u010das \u010d\u00edtania\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 min\u00fat\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/\",\"url\":\"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/\",\"name\":\"Lie\u010dba v\u010del\u00edm jedom na syst\u00e9mov\u00fa skler\u00f3zu \/sklerodermia\/ - apitoxin.sk\",\"isPartOf\":{\"@id\":\"http:\/\/apitoxin.sk\/#website\"},\"datePublished\":\"2022-07-20T06:27:16+00:00\",\"dateModified\":\"2022-07-20T06:27:17+00:00\",\"author\":{\"@id\":\"http:\/\/apitoxin.sk\/#\/schema\/person\/3432b72e01828705a1bdf176a0c88c35\"},\"breadcrumb\":{\"@id\":\"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/#breadcrumb\"},\"inLanguage\":\"sk-SK\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\/\/apitoxin.sk\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Lie\u010dba v\u010del\u00edm jedom na syst\u00e9mov\u00fa skler\u00f3zu \/sklerodermia\/\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/apitoxin.sk\/#website\",\"url\":\"http:\/\/apitoxin.sk\/\",\"name\":\"apitoxin.sk\",\"description\":\"Slovensk\u00fd v\u00fdrobca lapa\u010dov v\u010delieho jedu\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/apitoxin.sk\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"sk-SK\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/apitoxin.sk\/#\/schema\/person\/3432b72e01828705a1bdf176a0c88c35\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sk-SK\",\"@id\":\"http:\/\/apitoxin.sk\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/0.gravatar.com\/avatar\/06dd689f8b2c0a42278f99d7607e0cb1?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/0.gravatar.com\/avatar\/06dd689f8b2c0a42278f99d7607e0cb1?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"http:\/\/apitoxin.sk\"],\"url\":\"http:\/\/d.r5.wbsprt.com\/apitoxin.sk\/author\/trix\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Lie\u010dba v\u010del\u00edm jedom na syst\u00e9mov\u00fa skler\u00f3zu \/sklerodermia\/ - apitoxin.sk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/apitoxin.sk\/2022\/07\/20\/liecba-vcelim-jedom-na-systemovu-sklerozu-sklerodermia\/","og_locale":"sk_SK","og_type":"article","og_title":"Lie\u010dba v\u010del\u00edm jedom na syst\u00e9mov\u00fa skler\u00f3zu \/sklerodermia\/ - apitoxin.sk","og_description":"\u010co je systematick\u00e1 skler\u00f3za?M\u00f4\u017eeme ho definova\u0165 ako zriedkav\u00e9, ale chronick\u00e9 ochorenie, sp\u00f4soben\u00e9 z nezn\u00e1mych pr\u00ed\u010din, ktor\u00e9 je charakterizovan\u00e9 cievnymi abnormalitami a dif\u00faznou fibr\u00f3zou vn\u00fatorn\u00fdch org\u00e1nov, k\u013abov a ko\u017ee. Jeho diagn\u00f3za m\u00f4\u017ee by\u0165 stanoven\u00e1 iba na klinickej \u00farovni pomocou laborat\u00f3rnych testov. 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