{"id":197,"date":"2022-07-20T08:47:04","date_gmt":"2022-07-20T06:47:04","guid":{"rendered":"http:\/\/apitoxin.sk\/?p=197"},"modified":"2022-07-20T08:47:05","modified_gmt":"2022-07-20T06:47:05","slug":"vceli-jed-na-reumaticku-artritidu","status":"publish","type":"post","link":"http:\/\/d.r5.wbsprt.com\/apitoxin.sk\/2022\/07\/20\/vceli-jed-na-reumaticku-artritidu\/","title":{"rendered":"V\u010del\u00ed jed na reumatick\u00fa Artrit\u00eddu"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>\u010co je reumatoidn\u00e1 artrit\u00edda?<br>Reumatoidn\u00fa artrit\u00eddu m\u00f4\u017eeme definova\u0165 ako stav, po\u010das ktor\u00e9ho k\u013ab zost\u00e1va v neust\u00e1lom z\u00e1palovom stave. Reumatoidn\u00e1 artrit\u00edda sa v\u00e4\u010d\u0161inou vyskytuje u star\u0161\u00edch mu\u017eov a \u017eien a zriedkavo postihuje mlad\u00fdch mu\u017eov a \u017eeny. Z\u00e1kladn\u00e1 pr\u00ed\u010dina reumatoidnej artrit\u00eddy je st\u00e1le nejasn\u00e1, ale patr\u00ed do kateg\u00f3rie autoimunitn\u00fdch ochoren\u00ed. Autoimunitn\u00e9 ochorenie je ochorenie, pri ktorom sa imunitn\u00fd syst\u00e9m tela rozpadne a za\u010dne nap\u00e1da\u0165 jeho tkaniv\u00e1. Nem\u00f4\u017eeme poveda\u0165, \u017ee reumatoidn\u00e1 artrit\u00edda je dedi\u010dn\u00e9 ochorenie, ale v niektor\u00fdch pr\u00edpadoch m\u00f4\u017ee by\u0165 sp\u00f4soben\u00e9 dedi\u010dn\u00fdmi d\u00f4vodmi.\u200b<\/p>\n\n\n\n<p>Ak\u00e9 faktory m\u00f4\u017eu vies\u0165 alebo zhor\u0161i\u0165 reumatoidn\u00fa artrit\u00eddu?<br>Pod\u013ea odborn\u00edkov na zdravie je faj\u010denie jedn\u00fdm z najz\u00e1va\u017enej\u0161\u00edch vonkaj\u0161\u00edch rizikov\u00fdch faktorov, ktor\u00e9 m\u00f4\u017eu sp\u00f4sobi\u0165 reumatoidn\u00fa artrit\u00eddu. A pre \u017eeny, ktor\u00e9 s\u00fa ob\u00e9zne, je ve\u013emi \u013eahk\u00e9 sta\u0165 sa obe\u0165ou tejto choroby. Existuj\u00fa aj ur\u010dit\u00e9 du\u0161evn\u00e9 faktory, poranenia k\u013abov a infekcie, ktor\u00e9 m\u00f4\u017eu artrit\u00eddu zhor\u0161i\u0165 alebo iniciova\u0165. Pri sk\u00faman\u00ed faktorov, ktor\u00e9 m\u00f4\u017eu sp\u00f4sobi\u0165 reumatoidn\u00fa artrit\u00eddu, zohr\u00e1va \u00falohu aj zl\u00e1 strava a neakt\u00edvny \u017eivotn\u00fd \u0161t\u00fdl.<br>Ako sa diagnostikuje reumatoidn\u00e1 artrit\u00edda?<br>U niektor\u00fdch \u013eud\u00ed m\u00f4\u017ee toto ochorenie vyvola\u0165 viacer\u00e9 pr\u00edznaky. T\u00ed pacienti, ktor\u00ed maj\u00fa viacer\u00e9 probl\u00e9my s k\u013abmi, sa m\u00f4\u017eu necha\u0165 skontrolova\u0165 na reumatoidn\u00e9 faktory prostredn\u00edctvom vzoriek krvi. Pom\u00f4\u017ee to pri anal\u00fdze rozsahu, v akom m\u00f4\u017eu by\u0165 r\u00f4zne k\u013aby v kr\u00e1tkom \u010dase po\u0161koden\u00e9. K\u013ab postihnut\u00fd reumatoidnou artrit\u00eddou bude ma\u0165 opuch a hr\u00fabku a \u010derstv\u00e9 krvn\u00e9 cievy okolo neho.<\/p>\n\n\n\n<p>Klinick\u00e1 randomizovan\u00e1 \u0161t\u00fadia terapie v\u010del\u00edm bodnut\u00edm pri reumatoidnej artrit\u00edde<\/p>\n\n\n\n<p>Cie\u013e<br>Hlavn\u00fdm \u00fa\u010delom tejto klinickej \u0161t\u00fadie bolo presk\u00fama\u0165 terapeutick\u00fd \u00fa\u010dinok v\u010delieho jedu na lie\u010dbu RA (reumatoidnej artrit\u00eddy). Pre t\u00fato \u0161t\u00fadiu bol prijat\u00fd \u0161peci\u00e1lny re\u017eim na ur\u010denie \u00fa\u010dinnosti r\u00f4znych zlo\u017eiek v\u010delieho jedu.<\/p>\n\n\n\n<p>Met\u00f3da<br>Na toto vy\u0161etrenie bolo vybran\u00fdch 100 pacientov s reumatoidnou artrit\u00eddou, ktor\u00ed boli rozdelen\u00ed do dvoch r\u00f4znych skup\u00edn, ka\u017ed\u00e1 skupina mala 50 pacientov. Prv\u00e1 skupina bola skupina v\u010delieho jedu a druh\u00e1 skupina bola kontroln\u00e1 skupina. Pacientom patriacim do skupiny v\u010delieho jedu bol pod\u00e1van\u00fd v\u010del\u00ed jed ashi-points a Meloxicam (Mobic, 7,5 mg, b. i. d.), sulfasalaz\u00edn (0,5 g, t. i. d.) a metotrex\u00e1t (MTX, 7,5 mg\/w). A druhej skupine sa peror\u00e1lne pod\u00e1val meloxicam (Mobic, 7,5 mg, b. i. d.), sulfasalaz\u00edn (0,5 g, t. i. d.) a metotrex\u00e1t (MTX, 7,5 mg\/w).<\/p>\n\n\n\n<p>V prvej skupine boli ashi-body vybran\u00e9 pod\u013ea \u010dasti postihnutej reumatoidnou artrit\u00eddou a boli definovan\u00e9 ako hlavn\u00e9 ak\u00fatne body. Boli \u010falej roz\u0161\u00edren\u00e9 o \u010fal\u0161ie ak\u00fatne body diferenci\u00e1ciou syndr\u00f3mu. T\u00e1to lie\u010dba bola zalo\u017een\u00e1 na celkovom obdob\u00ed 3 mesiacov a d\u00e1vka sa pod\u00e1vala po prest\u00e1vke jedn\u00e9ho d\u0148a. Bola podan\u00e1 iba jedna d\u00e1vka.<\/p>\n\n\n\n<p>V\u00fdsledok<br>Po skon\u010den\u00ed obdobia experiment\u00e1lnej lie\u010dby sa uskuto\u010dnili r\u00f4zne porovnania. Zistilo sa, \u017ee sk\u00f3re trvania rannej stuhnutosti, 15-metrovej ch\u00f4dze, sily \u00fachopu, po\u010dtu opuchov k\u013abov, bolesti pri lisovan\u00ed, aktivity k\u013abov a stup\u0148a opuchu k\u013abov po lie\u010dbe v\u010del\u00edm jedom sa v\u00fdrazne zlep\u0161ili. Toto bolo zaznamenan\u00e9 v skupine lie\u010denej aj v skupine s v\u010del\u00edm jedom (P&lt;0,05, 0,01). \u010eal\u0161ie porovnanie medzi t\u00fdmito skupinami odhalilo, \u017ee sk\u00f3re trvania rannej stuhnutosti, po\u010dtu opuchov k\u013abov, bolesti pri lisovan\u00ed a opuchu k\u013abov a pod\u00e1van\u00fdch d\u00e1vok Mobicu a MTX boli v\u0161etky n\u00edzke v porovnan\u00ed so skupinou lie\u010denou (P&lt;0,05, 0,01). Sila \u00fachopu bola tie\u017e vy\u0161\u0161ia v skupine s v\u010del\u00edm jedom ako v skupine s liekom (P&lt;0,05). Nakoniec bola miera relapsov v skupine s BV v\u00fdznamne ni\u017e\u0161ia ako v skupine s liekmi a bola na P&lt;0,05, 12 % oproti 32 %.<\/p>\n\n\n\n<p>Rozhodnutie<br>D\u00e1 sa poveda\u0165, \u017ee kombinovan\u00fd \u00fa\u010dinok liekov a v\u010delieho jedu je ove\u013ea \u00fa\u010dinnej\u0161\u00ed ako \u00fa\u010dinok jednoduch\u00fdch liekov. Pri pou\u017eit\u00ed s \u200b\u200bv\u010del\u00edm jedom sa m\u00f4\u017ee zn\u00ed\u017ei\u0165 po\u010det in\u00fdch liekov, a t\u00fdm aj menej ved\u013eaj\u0161\u00edch \u00fa\u010dinkov. V\u010del\u00ed jed m\u00f4\u017ee pom\u00f4c\u0165 pri lie\u010dbe reumatoidnej artrit\u00eddy a kontrolova\u0165 mieru recid\u00edvy.<\/p>\n\n\n\n<p><strong>Zdroj:\u00a0<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18807725\"><strong>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18807725<\/strong><\/a><\/p>\n\n\n\n<p><strong>Akupunkt\u00fara v\u010delieho jedu pre reumatoidn\u00fa artrit\u00eddu: Systematick\u00fd preh\u013ead n\u00e1hodn\u00fdch klinick\u00fdch \u0161t\u00fadi\u00ed<\/strong><\/p>\n\n\n\n<p>\u00davod<br>RA (reumatoidn\u00e1 artrit\u00edda) je z\u00e1va\u017en\u00e1 z\u00e1palov\u00e1 autoimunitn\u00e1 porucha, ktor\u00e1 m\u00e1 za n\u00e1sledok deform\u00e1ciu, opuch, stuhnutos\u0165 a boles\u0165 k\u013abov. M\u00f4\u017ee tie\u017e vies\u0165 k rozvoju ankyl\u00f3zy &#8211; stuhnutosti sp\u00f4sobenej abnorm\u00e1lnou rigiditou a adh\u00e9ziou k\u013abu v d\u00f4sledku akejko\u013evek choroby alebo zranenia. T\u00e1to komplexn\u00e1 povaha artrit\u00eddy rob\u00ed lie\u010dbu n\u00e1ro\u010dnou, preto\u017ee zah\u0155\u0148a r\u00f4zne pr\u00edstupy. Lie\u010dba je zalo\u017een\u00e1 na zmiernen\u00ed z\u00e1palu a prin\u00e1\u0161a tak \u00fa\u013eavu pri opuchoch a bolestiach k\u013abu. To nakoniec pom\u00e1ha pri zlep\u0161ovan\u00ed stavu pacienta a tie\u017e zabra\u0148uje ak\u00e9muko\u013evek druhu trvalej invalidity. Ak sa reumatoidn\u00e1 artrit\u00edda nelie\u010di v\u010das, m\u00f4\u017ee vies\u0165 k \u0165a\u017ekej invalidite, funk\u010dn\u00fdm obmedzeniam a chronickej de\u0161trukcii k\u013abov.<\/p>\n\n\n\n<p>BV (v\u010del\u00ed jed) sa u\u017e dlho pou\u017e\u00edva vo forme BV injekci\u00ed, BV akupunkt\u00fary a \u017eiv\u00fdch v\u010del\u00edch \u017eihadiel. Na akupunkt\u00farnu lie\u010dbu sa v\u010del\u00ed jed pou\u017e\u00edva v zriedenej alebo \u010distej forme v akupunkt\u00farnych bodoch. Akupunkt\u00fara v\u010delieho jedu m\u00e1 viacero farmakologick\u00fdch aktiv\u00edt, ktor\u00e9 zah\u0155\u0148aj\u00fa protirakovinov\u00e9, antiartritick\u00e9, protiz\u00e1palov\u00e9 a analgetick\u00e9 \u00fa\u010dinky prostredn\u00edctvom sofistikovan\u00e9ho mechanizmu, ktor\u00fd aktivuje excita\u010dn\u00fd a centr\u00e1lny inhibi\u010dn\u00fd syst\u00e9m a moduluje imunitn\u00fd syst\u00e9m.<\/p>\n\n\n\n<p>R\u00f4zne laborat\u00f3rne \u0161t\u00fadie vykonan\u00e9 na zvierat\u00e1ch zaznamenali analgetick\u00e9 \u00fa\u010dinky akupunkt\u00fary v\u010delieho jedu v \u0161peci\u00e1lnych klinick\u00fdch podmienkach a sk\u00fa\u0161kach. \u0160t\u00fadie na zvierat\u00e1ch tie\u017e uk\u00e1zali, \u017ee v\u010del\u00ed jed vykazuje analgetick\u00e9, protiz\u00e1palov\u00e9 a antiartritick\u00e9 \u00fa\u010dinky sp\u00f4soben\u00e9 potla\u010den\u00edm expresie fosfolip\u00e1zy A2 a cyklooxygen\u00e1zy2 a zn\u00ed\u017een\u00edm hladiny l\u00e1tok reaguj\u00facich na kysl\u00edk, oxidu dusnat\u00e9ho, IL6, IL a n\u00e1doru faktor nekr\u00f3zy \u03b1. Na t\u00fdchto akci\u00e1ch sa podie\u013eaj\u00fa zl\u00fa\u010deniny v\u010delieho jedu, ktor\u00e9 zah\u0155\u0148aj\u00fa am\u00edny, peptidy a enz\u00fdmy. Hoci sa akupunkt\u00fara v\u010del\u00edm jedom pou\u017e\u00edva na lie\u010dbu reumatoidnej artrit\u00eddy a \u00fa\u010dinne p\u00f4sob\u00ed na zlep\u0161enie funkci\u00ed kontrolou sympt\u00f3mov, nie s\u00fa dostupn\u00e9 \u017eiadne klinick\u00e9 d\u00f4kazy, ktor\u00e9 by stanovili \u00farove\u0148 \u00fa\u010dinnosti a bezpe\u010dnosti akupunkt\u00fary v\u010del\u00edm jedom pri reumatoidnej artrit\u00edde z metaanal\u00fdzy alebo systematickej presk\u00famanie. Preto bolo d\u00f4le\u017eit\u00e9 vykona\u0165 systematick\u00fd preh\u013ead na ur\u010denie \u00fa\u010dinnosti a bezpe\u010dnosti akupunkt\u00fary v\u010delieho jedu na lie\u010dbu reumatoidnej artrit\u00eddy.<\/p>\n\n\n\n<p>Diskusia<br>V s\u00fa\u010dasnosti s\u00fa k dispoz\u00edcii iba klinick\u00e9 experimenty, ktor\u00e9 pom\u00e1haj\u00fa ur\u010di\u0165 \u00fa\u010dinky akupunkt\u00fary v\u010delieho jedu na reumatoidn\u00fa artrit\u00eddu. Aj ke\u010f s\u00fa d\u00f4kazy n\u00edzkej kvality, mo\u017eno s istotou vyhl\u00e1si\u0165, \u017ee akupunkt\u00fara v\u010del\u00edm jedom v\u00fdrazne zni\u017euje po\u010det opuchnut\u00fdch k\u013abov, citliv\u00fdch k\u013abov a rann\u00fa stuhnutos\u0165 a tie\u017e zni\u017euje boles\u0165 a tie\u017e pom\u00e1ha zlep\u0161ova\u0165 kvalitu \u017eivota pacientov s reumatoidnou chorobou. artrit\u00edda v porovnan\u00ed s norm\u00e1lnou injekciou fyziologick\u00e9ho roztoku.<\/p>\n\n\n\n<p>Treba poznamena\u0165, \u017ee aj systematick\u00e9 presk\u00famanie je pod vplyvom nieko\u013ek\u00fdch obmedzen\u00ed. Bola vykonan\u00e1 iba jedna vhodn\u00e1 \u0161t\u00fadia na ur\u010denie \u00falohy akupunkt\u00fary v\u010delieho jedu pri reumatoidnej artrit\u00edde. A po druh\u00e9, randomizovan\u00e1 kontrolovan\u00e1 klinick\u00e1 \u0161t\u00fadia bola vykonan\u00e1 vo v\u00fdchodnej \u00c1zii a \u0161t\u00fadie z tejto \u010dasti zemegule nie je mo\u017en\u00e9 aplikova\u0165 na medzin\u00e1rodnej \u00farovni z d\u00f4vodu nedostatku vonkaj\u0161ej racionality.<br>Po tretie, k\u00f3rejsk\u00ed v\u00fdskumn\u00edci m\u00f4\u017eu z\u00edska\u0165 pozit\u00edvne v\u00fdsledky, ale pre nedostatok metodol\u00f3gie nebolo mo\u017en\u00e9 v\u00fdsledky zhusti\u0165. A po \u0161tvrt\u00e9, ani po v\u00fdskyte cyklickej oneskorenej precitlivenosti u vybran\u00fdch subjektov nebol pozorovan\u00fd \u017eiadny druh sledovania.<br>Randomizovan\u00e1 klinick\u00e1 \u0161t\u00fadia, ktor\u00e1 je tu zahrnut\u00e1, vyu\u017e\u00edva injekciu fyziologick\u00e9ho roztoku v t\u00fdch akupunkt\u00farnych bodoch, kde bola akupunkt\u00fara v\u010delieho jedu pod\u00e1van\u00e1 v r\u00e1mci lie\u010dby s placebom. Placebo je d\u00f4le\u017eit\u00e9 na stanovenie rozdielneho \u00fa\u010dinku medzi \u0161pecifick\u00fdmi a ne\u0161pecifick\u00fdmi formami lie\u010dby. Ak mo\u017eno predpoklada\u0165, \u017ee \u00fa\u010dinky akupunkt\u00fary v\u010delieho jedu mo\u017eno za\u017ei\u0165 stimul\u00e1ciou akupunkt\u00farnych bodov prostredn\u00edctvom imunomodula\u010dn\u00e9ho \u00fa\u010dinku v\u010delieho jedu, potom je tie\u017e d\u00f4le\u017eit\u00e9 vykona\u0165 \u010fal\u0161ie randomizovan\u00e9 kontrolovan\u00e9 klinick\u00e9 \u0161t\u00fadie, ktor\u00e9 m\u00f4\u017eu vyu\u017ei\u0165 spr\u00e1vne pod\u00e1vanie placeba. .<\/p>\n\n\n\n<p>Ak nie je k dispoz\u00edcii dostato\u010dn\u00fd po\u010det randomizovan\u00fdch klinick\u00fdch \u0161t\u00fadi\u00ed, m\u00f4\u017eu by\u0165 u\u017eito\u010dn\u00e9 in\u00e9 d\u00f4kazy. Pod\u013ea inej pozorovacej \u0161t\u00fadie boli pozorovan\u00e9 pozit\u00edvne \u00fa\u010dinky akupunkt\u00fary v\u010delieho jedu na sympt\u00f3my reumatoidnej artrit\u00eddy. Ale t\u00e1to \u0161t\u00fadia mala svoje nedostatky. Ch\u00fdbali mu ur\u010dit\u00e9 kontroly, a preto bol otvoren\u00fd v\u00fdberov\u00e9mu skresleniu, ktor\u00e9 by nakoniec mohlo vies\u0165 k falo\u0161ne pozit\u00edvnym v\u00fdsledkom.<br>Pri tradi\u010dnej akupunkt\u00farnej lie\u010dbe v\u010del\u00edm jedom dost\u00e1vaj\u00fa pacienti s reumatoidnou artrit\u00eddou \u017eiv\u00e9 v\u010delie bodnutie a t\u00e1to prax je v \u010c\u00edne ve\u013emi be\u017en\u00e1. V tejto s\u00favislosti sa na\u0161li \u0161tyri r\u00f4zne \u0161t\u00fadie, v ktor\u00fdch sa akupunkt\u00fara so \u017eiv\u00fdm v\u010del\u00edm jedom pod\u00e1vala s konven\u010dnou lie\u010dbou a liekmi na lie\u010dbu sympt\u00f3mov reumatoidnej artrit\u00eddy. Zo 4, 3 randomizovan\u00e9 kontrolovan\u00e9 klinick\u00e9 \u0161t\u00fadie preuk\u00e1zali priazniv\u00fd vplyv akupunkt\u00fary v\u010delieho jedu na celkov\u00fd stav subjektu. Zistilo sa, \u017ee rann\u00e1 stuhnutos\u0165, boles\u0165 k\u013abov a opuch k\u013abov nie s\u00fa tak\u00e9 v\u00fdrazn\u00e9 ako pred lie\u010dbou akupunkt\u00farou v\u010del\u00edm jedom. V\u0161etky vy\u0161\u0161ie uveden\u00e9 klinick\u00e9 \u0161t\u00fadie nezaznamenali \u017eiadne z\u00e1va\u017en\u00e9 ne\u017eiaduce \u00fa\u010dinky akupunkt\u00farnej terapie v\u010del\u00edm jedom.<\/p>\n\n\n\n<p>Z\u00e1vere\u010dn\u00e9 stanovisko<br>Na z\u00e1ver mo\u017eno poveda\u0165, \u017ee len nieko\u013eko klinick\u00fdch \u0161t\u00fadi\u00ed ur\u010dilo \u00fa\u010dinky akupunkt\u00fary v\u010delieho jedu na zvl\u00e1dnutie reumatoidnej artrit\u00eddy. A dostupn\u00e9 d\u00f4kazy tie\u017e nesta\u010dia na to, aby sa dalo vyhl\u00e1si\u0165, \u017ee akupunkt\u00fara v\u010del\u00edm jedom je najlep\u0161ou a naj\u00fa\u010dinnej\u0161ou terapiou na potla\u010denie sympt\u00f3mov reumatoidnej artrit\u00eddy. Vy\u017eaduj\u00fa sa \u010fal\u0161ie klinick\u00e9 \u0161t\u00fadie, ktor\u00e9 by mali ma\u0165 vysokokvalitn\u00fd syst\u00e9m s osobitn\u00fdm d\u00f4razom na v\u00fdvoj dizajnu, ktor\u00fd je vhodn\u00fd a primeran\u00fd pre kontroln\u00e9 skupiny.<\/p>\n\n\n\n<p><strong>Zdroj:\u00a0<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4225238\/\"><strong>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4225238\/<\/strong><\/a><\/p>\n\n\n\n<p><strong>V\u010del\u00ed jed m\u00e1 antinocicept\u00edvne a protiz\u00e1palov\u00e9 \u00fa\u010dinky na reumatoidn\u00fa artrit\u00eddu<\/strong><\/p>\n\n\n\n<p>\u00davod<br>Ned\u00e1vno sa preuk\u00e1zalo, \u017ee injekcia BV (v\u010del\u00ed jed) v ST36 (Zusanli acupoint) priniesla \u017eivotaschopnej\u0161\u00ed antinocicept\u00edvny a protiz\u00e1palov\u00fd \u00fa\u010dinok v porovnan\u00ed s injekciou podanou v non-acupoint. T\u00e1to klinick\u00e1 \u0161t\u00fadia sa uskuto\u010dnila na Freundovom modeli reumatoidnej artrit\u00eddy vyvolanej adjuvans. Bolo pozorovan\u00e9, \u017ee konkr\u00e9tne zlo\u017eky v\u010delieho jedu, ktor\u00e9 s\u00fa zodpovedn\u00e9 za poskytovanie tohto protiz\u00e1palov\u00e9ho a antinocicept\u00edvneho \u00fa\u010dinku, e\u0161te nie s\u00fa \u00faplne pochopen\u00e9.<\/p>\n\n\n\n<p>Met\u00f3da<br>Cel\u00fd v\u010del\u00ed jed bol extrahovan\u00fd a rozdelen\u00fd do dvoch frakci\u00ed v z\u00e1vislosti od rozpustnosti \u2013 jedna bola BVE (rozpustn\u00e1 frakcia v etylacet\u00e1te) a druh\u00e1 bola BVA (vo vode rozpustn\u00e1 frakcia). Frakcia BVA bola \u010falej testovan\u00e1, aby sa ur\u010dila \u00faloha rozpustn\u00fdch frakci\u00ed pri vytv\u00e1ran\u00ed antiartritick\u00fdch \u00fa\u010dinkov na subjekty s reumatoidnou artrit\u00eddou.<\/p>\n\n\n\n<p>Diskusia<br>Subkut\u00e1nna akupunkt\u00farna injekcia v\u010delieho jedu s d\u00e1vkou 0,9 mg\/kg sa pod\u00e1vala do akupunkt\u00fary ST36 denne a zistilo sa, \u017ee v\u00fdznamne inhibuje r\u00e1diologick\u00e9 zmeny a zmeny ed\u00e9mu labky (opuch m\u00e4kk\u00fdch tkan\u00edv a prolifer\u00e1ciu novej kosti) v d\u00f4sledku injekcie Freundovho adjuvans. Tie\u017e sa zistilo, \u017ee lie\u010dba v\u010del\u00edm jedom zn\u00ed\u017eila s\u00e9rov\u00fd interleuk\u00edn-6, ktor\u00fd je sp\u00f4soben\u00fd indukciou reumatoidnej artrit\u00eddy, na \u00farove\u0148 zisten\u00fa v neartritick\u00fdch modeloch. Terapia v\u010del\u00edm jedom tie\u017e zn\u00ed\u017eila artrit\u00eddu a priniesla nocicept\u00edvne spr\u00e1vanie, ako napr\u00edklad nocicept\u00edvne sk\u00f3re pre tepeln\u00fa hyperalg\u00e9ziu a mechanick\u00fa hyperalg\u00e9ziu.<\/p>\n\n\n\n<p>Nakoniec akupunkt\u00farna lie\u010dba v\u010del\u00edm jedom v\u00fdrazne potla\u010dila adjuvantne presved\u010den\u00fa expresiu c-Fos v lumb\u00e1lnej mieche po troch t\u00fd\u017ed\u0148och injek\u010dnej lie\u010dby. Zatia\u013e \u010do lie\u010dba BVE pod\u00e1van\u00e1 v d\u00e1vke 0,05 mg\/kg za de\u0148 nepreuk\u00e1zala \u017eiadny druh antinocicept\u00edvnych alebo protiz\u00e1palov\u00fdch \u00fa\u010dinkov na modeloch reumatoidnej artrit\u00eddy. V\u00fdsledky z\u00edskan\u00e9 z tejto klinickej \u0161t\u00fadie nazna\u010duj\u00fa, \u017ee: akupunkt\u00fara v\u010delieho jedu je jedinou \u00fa\u010dinnou frakciou extrahovanou z cel\u00e9ho v\u010delieho jedu, ktor\u00e1 vedie k protiz\u00e1palov\u00fdm a antinocicept\u00edvnym \u00fa\u010dinkom.<\/p>\n\n\n\n<p>Z\u00e1ver<br>Preto sa d\u00f4razne odpor\u00fa\u010da pou\u017e\u00edva\u0165 t\u00fato konkr\u00e9tnu frakciu v\u010delieho jedu z dlhodob\u00e9ho h\u013eadiska na lie\u010dbu sympt\u00f3mov z\u00e1palu a bolesti podobn\u00e9ho reumatoidnej artrit\u00edde.<\/p>\n\n\n\n<p><strong>Zdroj:\u00a0<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12031688\"><strong>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12031688<\/strong><\/a><\/p>\n\n\n\n<p><strong>Akupunkt\u00fara v\u010delieho jedu pre reumatoidn\u00fa artrit\u00eddu: protokol o systematickom presk\u00faman\u00ed<\/strong><\/p>\n\n\n\n<p>\u00davod<br>Systematick\u00e9 preh\u013eady s\u00fa pomerne rozsiahle, preto\u017ee sa vykon\u00e1vaj\u00fa na z\u00e1klade nestrann\u00e9ho vyh\u013ead\u00e1vania r\u00f4znych datab\u00e1z s\u00favisiacich s BVA bez zoh\u013eadnenia jazykovej bari\u00e9ry. Dvaja v\u00fdskumn\u00edci vykon\u00e1vaj\u00fa nez\u00e1visl\u00fd skr\u00edning a extrakciu \u00fadajov. Ke\u010f\u017ee len m\u00e1lo klinick\u00fdch \u0161t\u00fadi\u00ed nie je konkurencieschopn\u00fdch, je \u0165a\u017ek\u00e9 pr\u00eds\u0165 s riadnym preh\u013eadom.<\/p>\n\n\n\n<p>Systematick\u00fd preh\u013ead je d\u00f4le\u017eit\u00fd, preto\u017ee sk\u00fama h\u013abkov\u00e9, r\u00f4zne klinick\u00e9 \u0161t\u00fadie, ktor\u00e9 sa uskuto\u010dnili na ur\u010denie \u00falohy BVA pre RA. Pre t\u00fato recenziu bolo presk\u00faman\u00fdch 14 r\u00f4znych datab\u00e1z a zah\u0155\u0148ali: Wanfang, VIP, CNKI (\u010c\u00ednska n\u00e1rodn\u00e1 znalostn\u00e1 infra\u0161trukt\u00fara), K\u00f3rejsk\u00e1 lek\u00e1rska datab\u00e1za, DBPIA, KoreaMed, Syst\u00e9m informa\u010dn\u00fdch slu\u017eieb k\u00f3rejsk\u00fdch \u0161t\u00fadi\u00ed, K\u00f3rejsk\u00fd tradi\u010dn\u00fd znalostn\u00fd port\u00e1l, OASIS, CINAHL, AMED, Centr\u00e1lny register kontrolovan\u00fdch \u0161t\u00fadi\u00ed Cochrane (CENTRAL), EMBASE a MEDLINE.<\/p>\n\n\n\n<p><strong>Zdroj:\u00a0<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4010843\/\"><strong>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4010843\/<\/strong><\/a><\/p>\n\n\n\n<p>Z\u00e1ver<br>Nakoniec sa zistilo, \u017ee akupunkt\u00fara v\u010delieho jedu m\u00f4\u017ee pom\u00f4c\u0165 zmierni\u0165 pr\u00edznaky reumatoidnej artrit\u00eddy, ak sa pod\u00e1va v r\u00e1mci kontrolovanej d\u00e1vky a pl\u00e1nu cyklu. Na objasnenie \u00falohy r\u00f4znych zlo\u017eiek akupunkt\u00fary v\u010delieho jedu, ktor\u00e9 maj\u00fa tieto antiartritick\u00e9 \u00fa\u010dinky, s\u00fa potrebn\u00e9 \u010fal\u0161ie h\u013abkov\u00e9 klinick\u00e9 \u0161t\u00fadie.<\/p>\n\n\n\n<p><strong>Zdroj:<\/strong><br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18807725\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical randomized study of bee-sting therapy for rheumatoid arthritis.<\/a><br><a href=\"https:\/\/jama.jamanetwork.com\/article.aspx?articleid=260033\" target=\"_blank\" rel=\"noreferrer noopener\">Bee Venom Therapy: Bee Venom, Its Nature, and Its Effect on Arthritic and Rheumatoid Conditions.<\/a><br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4225238\/\">Bee venom\u00a0acupuncture for rheumatoid arthritis: a systematic review of randomized clinical trials<\/a><br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4010843\/\">Bee venom\u00a0acupuncture for rheumatoid arthritis: a systematic review protocol<br>\u200b<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2445826\/\">Bee Venom\u00a0for Rheumatism<br>\u200b<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12031688\" target=\"_blank\" rel=\"noreferrer noopener\">Bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritis.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u010co je reumatoidn\u00e1 artrit\u00edda?Reumatoidn\u00fa artrit\u00eddu m\u00f4\u017eeme definova\u0165 ako stav, po\u010das ktor\u00e9ho k\u013ab zost\u00e1va v neust\u00e1lom z\u00e1palovom stave. Reumatoidn\u00e1 artrit\u00edda sa v\u00e4\u010d\u0161inou vyskytuje u star\u0161\u00edch mu\u017eov a \u017eien a zriedkavo postihuje mlad\u00fdch mu\u017eov a \u017eeny. Z\u00e1kladn\u00e1 pr\u00ed\u010dina reumatoidnej artrit\u00eddy je st\u00e1le nejasn\u00e1, ale patr\u00ed do kateg\u00f3rie autoimunitn\u00fdch ochoren\u00ed. Autoimunitn\u00e9 ochorenie je ochorenie, pri ktorom sa imunitn\u00fd [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":198,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"ngg_post_thumbnail":0},"categories":[7],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>V\u010del\u00ed jed na reumatick\u00fa Artrit\u00eddu - apitoxin.sk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/apitoxin.sk\/2022\/07\/20\/vceli-jed-na-reumaticku-artritidu\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"V\u010del\u00ed jed na reumatick\u00fa Artrit\u00eddu - apitoxin.sk\" \/>\n<meta property=\"og:description\" content=\"\u010co je reumatoidn\u00e1 artrit\u00edda?Reumatoidn\u00fa artrit\u00eddu m\u00f4\u017eeme definova\u0165 ako stav, po\u010das ktor\u00e9ho k\u013ab zost\u00e1va v neust\u00e1lom z\u00e1palovom stave. 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