<\/p>\n\n\n\n
Akn\u00e9 \u2013 je jedn\u00fdm z najbe\u017enej\u0161\u00edch typov ko\u017en\u00fdch ochoren\u00ed. St\u00e1va sa to, ke\u010f sa mal\u00e9 vlasov\u00e9 folikuly zablokuj\u00fa odumretou ko\u017eou a ved\u00fa k produkcii ko\u017en\u00e9ho mazu. A to v d\u00f4sledku toho vedie k pupienkom a vyr\u00e1\u017ekam naz\u00fdvan\u00fdm akn\u00e9.<\/p>\n\n\n\n
Inhibi\u010dn\u00e9 \u00fa\u010dinky v\u010delieho jedu na z\u00e1palov\u00e9 ko\u017en\u00e9 ochorenie vyvolan\u00e9 Propionibacterium Acnes na zvieracom modeli \u00davod
P. acnes (propionibacterium acnes), typ ko\u017en\u00e9ho akn\u00e9, je jedn\u00fdm z hlavn\u00fdch faktorov, ktor\u00e9 prispievaj\u00fa k z\u00e1palov\u00e9mu modulu akn\u00e9. Lieky na predpis ur\u010den\u00e9 na lie\u010dbu akn\u00e9 vyu\u017e\u00edvaj\u00fa kombin\u00e1ciu r\u00f4znych sp\u00f4sobov lie\u010dby. Zah\u0155\u0148aj\u00fa siln\u00e9 antibiotik\u00e1, ktor\u00e9 okrem ich nieko\u013ek\u00fdch pozit\u00edvnych antibakteri\u00e1lnych \u00fa\u010dinkov ved\u00fa k ved\u013eaj\u0161\u00edm \u00fa\u010dinkom. Naj\u010dastej\u0161ie tieto lieky sp\u00f4sobuj\u00fa potla\u010denie z\u00e1palov\u00fdch reakci\u00ed hostite\u013ea.<\/p>\n\n\n\n
Met\u00f3da: BV (pre\u010disten\u00fd v\u010del\u00ed jed) obsahuje Apis mellifera, ktor\u00fd je neoddelite\u013enou s\u00fa\u010das\u0165ou modern\u00fdch lie\u010debn\u00fdch re\u017eimov. Pou\u017e\u00edva sa aj v tradi\u010dnej medic\u00edne na lie\u010denie r\u00f4znych chor\u00f4b a chor\u00f4b. T\u00e1to \u0161t\u00fadia bola vykonan\u00e1 s dvoma r\u00f4znymi skupinami, aby sa presk\u00famal terapeutick\u00fd \u00fa\u010dinok v\u010delieho jedu proti p. akn\u00e9. Po prv\u00e9, my\u0161iam oboch skup\u00edn bola podan\u00e1 injekcia p. acnes intraderm\u00e1lne, aby sa u nich vyvolalo z\u00e1palov\u00e9 ochorenie ko\u017ee. Nesk\u00f4r bol len jednej skupine podan\u00fd v\u010del\u00ed jed, aby bolo mo\u017en\u00e9 vykona\u0165 porovnanie.<\/p>\n\n\n\n
Po vyvolan\u00ed predmetn\u00e9ho modelu my\u0161\u00ed s p. akn\u00e9, v\u010del\u00ed jed bol aplikovan\u00fd pr\u00e1ve na tom istom mieste, kde p. akne bolo dane. Pod\u013ea histologick\u00e9ho pozorovania sa zistilo, \u017ee p. indukcia akn\u00e9 v pravom uchu vedie k vidite\u013en\u00e9mu zv\u00fd\u0161eniu popul\u00e1cie infiltrovan\u00fdch z\u00e1palov\u00fdch buniek. Ale po o\u0161etren\u00ed v\u010del\u00edm jedom bola t\u00e1to \u0161pecifick\u00e1 reakcia kontrolovan\u00e1 v p. u my\u0161\u00ed vyvolan\u00fdch akn\u00e9 v porovnan\u00ed s my\u0161ami, ktor\u00fdm nebol podan\u00fd v\u010del\u00ed jed.<\/p>\n\n\n\n
Hladiny expresie interleuk\u00ednu (IL) – 1p a tumor nekrotizuj\u00faceho faktora (TNF) a boli pozoruhodne indukovan\u00e9 u my\u0161\u00ed lie\u010den\u00fdch v\u010del\u00edm jedom v porovnan\u00ed s t\u00fdmi, ktor\u00e9 neboli lie\u010den\u00e9. Okrem toho lie\u010dba v\u010del\u00edm jedom ohromne zabr\u00e1nila expresii CD14 a TLR2 v p. akn\u00e9 injek\u010dn\u00e9 tkanivo. V\u00e4zbov\u00e1 aktivita AP1 (aktiv\u00e1torov\u00fd prote\u00edn) a NF\u03baB (jadrov\u00fd faktor kp) sa tie\u017e zn\u00ed\u017eila po o\u0161etren\u00ed v\u010del\u00edm jedom.<\/p>\n\n\n\n
V\u00fdsledok
Pod\u013ea tejto \u0161t\u00fadie, ktor\u00e1 vyu\u017e\u00edvala zvierac\u00ed model, mo\u017eno poveda\u0165, \u017ee v\u010del\u00ed jed m\u00e1 inhibi\u010dn\u00fd \u00fa\u010dinok na z\u00e1palov\u00e9 ochorenia. \u00dadaje z\u00edskan\u00e9 z tejto klinickej \u0161t\u00fadie tie\u017e nazna\u010duj\u00fa, \u017ee v\u010del\u00ed jed m\u00f4\u017ee by\u0165 pou\u017eit\u00fd ako siln\u00fd prostriedok proti akn\u00e9 v r\u00f4znych kozmetick\u00fdch a farmaceutick\u00fdch produktoch.<\/p>\n\n\n\n
Zdroj: \u200b\u200b<\/a>Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Akn\u00e9 \u2013 je jedn\u00fdm z najbe\u017enej\u0161\u00edch typov ko\u017en\u00fdch ochoren\u00ed. St\u00e1va sa to, ke\u010f sa mal\u00e9 vlasov\u00e9 folikuly zablokuj\u00fa odumretou ko\u017eou a ved\u00fa k produkcii ko\u017en\u00e9ho mazu. A to v d\u00f4sledku toho vedie k pupienkom a vyr\u00e1\u017ekam naz\u00fdvan\u00fdm akn\u00e9. Inhibi\u010dn\u00e9 \u00fa\u010dinky v\u010delieho jedu na z\u00e1palov\u00e9 ko\u017en\u00e9 ochorenie vyvolan\u00e9 Propionibacterium Acnes na zvieracom modeli \u00davodP. acnes (propionibacterium […]<\/p>\n","protected":false},"author":1,"featured_media":92,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"ngg_post_thumbnail":0},"categories":[7],"tags":[],"yoast_head":"\n