{"id":93,"date":"2022-07-13T10:16:46","date_gmt":"2022-07-13T08:16:46","guid":{"rendered":"http:\/\/apitoxin.sk\/?p=93"},"modified":"2022-07-13T12:37:37","modified_gmt":"2022-07-13T10:37:37","slug":"liecba-vcelim-jedom-pre-alopecia-areata","status":"publish","type":"post","link":"http:\/\/d.r5.wbsprt.com\/apitoxin.sk\/2022\/07\/13\/liecba-vcelim-jedom-pre-alopecia-areata\/","title":{"rendered":"Lie\u010dba v\u010del\u00edm jedom pre ALOPECIA AREATA"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>Alopecia areata je org\u00e1novo \u0161pecifick\u00fd autoimunitn\u00fd proces, ktor\u00fd ni\u010d\u00ed vlasov\u00e9 folikuly. Presn\u00e9 pr\u00ed\u010diny v\u00fdskytu Alopecia areata st\u00e1le nie s\u00fa zn\u00e1me. Be\u017ene sa hovor\u00ed, \u017ee emocion\u00e1lny stres alebo ur\u010dit\u00e1 infekcia sp\u00fa\u0161\u0165a vypad\u00e1vanie vlasov. Zistilo sa, \u017ee postihuje najm\u00e4 \u013eud\u00ed, patriacich do vekovej kateg\u00f3rie medzi 20. a 50. rokom \u017eivota. Neexistuje \u017eiadna rodov\u00e1 diskrimin\u00e1cia ani zov\u0161eobec\u0148ovanie; m\u00f4\u017ee zasiahnu\u0165 mu\u017eov aj \u017eeny tejto vekovej skupiny.<\/p>\n\n\n\n<p>Zo za\u010diatku sa za\u010dn\u00fa objavova\u0165 lys\u00e9 miesta, ktor\u00e9 nie s\u00fa v\u00e4\u010d\u0161ie ako 2 cm alebo 3 cm, nesk\u00f4r m\u00f4\u017eu \u0161kvrny v priebehu nieko\u013ek\u00fdch t\u00fd\u017ed\u0148ov alebo mesiacov prer\u00e1s\u0165 do ve\u013ek\u00fdch f\u013eakov. V niektor\u00fdch pr\u00edpadoch tieto \u0161kvrny samy zmizn\u00fa a potom sa znova objavia. Takmer 90% \u013eud\u00ed v ur\u010ditom okamihu za\u017eije alop\u00e9ciu areata, ktor\u00e1 nevedie k \u00faplnej strate vlasov. S\u00fa to mal\u00e9 ple\u0161at\u00e9 \u0161kvrny, ktor\u00e9 sa pravidelne prejavuj\u00fa.<\/p>\n\n\n\n<p><strong>Pr\u00edpad alopecie areata lie\u010denej v\u010del\u00edm jedom a bylinnou akupunkt\u00farou Carthami Flos<\/strong><br>Alopecia areata je jednou z najbe\u017enej\u0161\u00edch chor\u00f4b, ktor\u00e9 je \u0165a\u017ek\u00e9 rie\u0161i\u0165 z h\u013eadiska lek\u00e1rskeho mana\u017ementu. T\u00e1to klinick\u00e1 \u0161t\u00fadia bola navrhnut\u00e1 na presk\u00famanie kumulat\u00edvneho \u00fa\u010dinku BV \/v\u010delieho jedu\/ a Carthami Flos (bylinn\u00e1 akupunkt\u00fara).<\/p>\n\n\n\n<p>Je dobre zn\u00e1me, \u017ee lie\u010dba Alopecia Areata je trochu n\u00e1ro\u010dn\u00e1. Vo svetle tejto \u0161t\u00fadie sa sk\u00famal celkov\u00fd \u00fa\u010dinok jedu v\u010diel medonosn\u00fdch. Spolu s v\u010del\u00edm jedom sa \u0161tudovala aj \u010fal\u0161ia bylinn\u00e1 akupunkt\u00fara carthami flos.<\/p>\n\n\n\n<p>Pod\u013ea prijatej met\u00f3dy bol pacientovi podan\u00fd v\u010del\u00ed jed, carthami-flos a celkov\u00e1 akupunkt\u00fara. Carthami Flos bol injek\u010dne podan\u00fd intraven\u00f3znou met\u00f3dou priamo do miesta poranenia. Jeho \u00fa\u010dinok na oblas\u0165 alopecia areata bol d\u00f4kladne hodnoten\u00fd.<\/p>\n\n\n\n<p>Subjekt dostal v\u010del\u00ed jed, carthami flos a v\u0161eobecn\u00fa akupunkt\u00faru. Carthami flos bol injikovan\u00fd priamo do l\u00e9zie. Jeho zapojenie do plaku bolo kontrolovan\u00e9 s oh\u013eadom na \u00fa\u010dinok na alopecia areata. Po nepretr\u017eitej lie\u010dbe trvaj\u00facej 5 mesiacov sa zistilo, \u017ee l\u00e9ziu nahradili nov\u00e9 termin\u00e1lne vlasy.<\/p>\n\n\n\n<p>Zistilo sa, \u017ee po 5 mesiacoch pravidelnej lie\u010dby sa na mieste poranenia za\u010dali objavova\u0165 nov\u00e9 vlasy. Je to jasn\u00fd d\u00f4kaz, \u017ee v\u010del\u00ed jed plus akupunkt\u00fara carthami flos m\u00e1 pozit\u00edvny vplyv na alopecia areata. T\u00e1to \u0161t\u00fadia v\u0161ak ur\u010dite nie je kone\u010dn\u00fdm slovom. Na ur\u010denie presn\u00e9ho d\u00e1vkovania a sp\u00f4sobu lie\u010dby alopecia areata pomocou v\u010delieho jedu a carthami flos s\u00fa potrebn\u00e9 \u010fal\u0161ie klinick\u00e9 testovacie cykly.<\/p>\n\n\n\n<p>Pri zv\u00fd\u0161en\u00ed sk\u00f3re z 0 na 3 body bol evidentn\u00fd \u00fa\u010dinok na alopecia areata. Tento v\u00fdsledok uk\u00e1zal, \u017ee BV \/v\u010deli jed\/ a carthami flos maj\u00fa pozit\u00edvny vplyv na alopecia areata. Napriek tomu je potrebn\u00e1 podrobnej\u0161ia klinick\u00e1 \u0161t\u00fadia na preuk\u00e1zanie kombinovan\u00fdch \u00fa\u010dinkov BV\/v\u010delieho jedu\/ a carthami flos na rie\u0161enie sympt\u00f3mov alopecia areata.<\/p>\n\n\n\n<p><strong>V\u010del\u00ed jed podporuje rast vlasov v spojen\u00ed s inhib\u00edciou expresie 5\u03b1-redukt\u00e1zy<\/strong><br>Alopecia je be\u017en\u00fd probl\u00e9m, ktor\u00fd m\u00f4\u017ee postihn\u00fa\u0165 \u013eud\u00ed akejko\u013evek vekovej skupiny. Pod\u013ea posledn\u00fdch klinick\u00fdch \u0161t\u00fadi\u00ed sa do ve\u013ekej miery dok\u00e1zalo, \u017ee v\u010del\u00ed jed pom\u00e1ha pri lie\u010dbe: neuralgie, reumatoidnej artrit\u00eddy a roztr\u00fasenej skler\u00f3zy.<\/p>\n\n\n\n<p>Na uskuto\u010dnenie tejto \u0161t\u00fadie sa na sami\u010dk\u00e1ch my\u0161\u00ed po\u010das 19 dn\u00ed pou\u017eil v\u010del\u00ed jed (0,001 %, 0,005 % a 0,01 %) a minoxidil (2 %). V\u0161etky tieto faktory, ktor\u00e9 prispievaj\u00fa k rastu vlasov, boli podrobne sk\u00faman\u00e9 prostredn\u00edctvom anal\u00fdzy Western blot a kvantitat\u00edvnej PCR v re\u00e1lnom \u010dase. Po\u010das procesu sa pou\u017eili bunky \u013eudskej derm\u00e1lnej papily a ko\u017ee my\u0161\u00ed.<\/p>\n\n\n\n<p>Bolo pozorovan\u00e9, \u017ee v\u010del\u00ed jed podporuje rast nov\u00fdch vlasov a vykazuje prechod z anag\u00e9nnej do katag\u00e9nnej f\u00e1zy. Po\u010das oboch f\u00e1z bol rast vlasov z\u00e1visl\u00fd od d\u00e1vky a jej pod\u00e1vania.<\/p>\n\n\n\n<p>\u010ealej to vysvet\u013euje, \u017ee v\u010del\u00ed jed potl\u00e1\u010dal expresiu SRD5A2, ktor\u00e1 k\u00f3duje 5a-redukt\u00e1zu typu II. Hr\u00e1 d\u00f4le\u017eit\u00fa \u00falohu pri premene testoster\u00f3nu na dihydrotestoster\u00f3n. Prolifer\u00e1cia rastov\u00fdch faktorov (fibroblastov\u00fd rastov\u00fd faktor, vaskul\u00e1rny endoteli\u00e1lny rastov\u00fd faktor a receptor inzul\u00ednov\u00e9ho rastov\u00e9ho faktora 1) stimulovan\u00e1 pr\u00edtomnos\u0165ou hDPC u subjektov lie\u010den\u00fdch v\u010del\u00edm jedom sa porovn\u00e1vala s kontrolnou skupinou. Zistilo sa, \u017ee v\u010del\u00ed jed podporuje rast vlasov, preto\u017ee je siln\u00fdm inhib\u00edtorom 5\u03b1-redukt\u00e1zy.<\/p>\n\n\n\n<p><strong>Akupunkt\u00fara na lie\u010dbu alopecie areata: Protokol systematick\u00e9ho preh\u013eadu randomizovan\u00fdch klinick\u00fdch \u0161t\u00fadi\u00ed: Obr\u00e1zok 1<\/strong><br>Technika akupunkt\u00fary sa v\u00e4\u010d\u0161inou pou\u017e\u00edva v dermatol\u00f3gii na n\u00e1pravu r\u00f4znych ko\u017en\u00fdch por\u00fach. Nie s\u00fa v\u0161ak k dispoz\u00edcii \u017eiadne cenn\u00e9 d\u00f4kazy na podporu potenci\u00e1lnych v\u00fdhod akupunkt\u00fary na lie\u010dbu alopecia areata.<\/p>\n\n\n\n<p>Hne\u010f od za\u010diatku bolo preh\u013eadan\u00fdch 13 r\u00f4znych datab\u00e1z. I\u0161lo o 6 k\u00f3rejsk\u00fdch lek\u00e1rskych datab\u00e1z (Koreamed a K\u00f3rejsk\u00e1 kni\u017enica n\u00e1rodn\u00e9ho zhroma\u017edenia, V\u00fdskumn\u00e1 slu\u017eba zdie\u013eania inform\u00e1ci\u00ed, Mestsk\u00e1 spolo\u010dnos\u0165 pre vedu a technol\u00f3giu, DBPIA, Syst\u00e9m informa\u010dn\u00fdch slu\u017eieb k\u00f3rejsk\u00fdch \u0161t\u00fadi\u00ed), 3 \u010d\u00ednske datab\u00e1zy (datab\u00e1za Wanfang, \u010d\u00ednska periodick\u00e1 datab\u00e1za vedy a techniky Chongging VIP (VIP) a China National Knowledge Infrastructure Database) Cochrane Library, EMBASE, AMED a PubMed.<\/p>\n\n\n\n<p>Zva\u017eovali sa iba randomizovan\u00e9 klinick\u00e9 \u0161t\u00fadie, ktor\u00e9 vyu\u017e\u00edvali akupunkt\u00faru na lie\u010dbu alopecia areata. \u00da\u010dastn\u00edci klinick\u00fdch sk\u00fa\u0161ok nemali \u017eiadne obmedzenia t\u00fdkaj\u00face sa veku, pohlavia a pr\u00ed\u010din. Pod\u013ea prijatej met\u00f3dy bol protokol tejto rozsiahlej systematickej kontroly zaregistrovan\u00fd na PROSPERO s registra\u010dn\u00fdm \u010d\u00edslom CRD42015020397. Rozhodlo sa tie\u017e, \u017ee presk\u00famanie sa bude vykon\u00e1va\u0165 a pod\u00e1va\u0165 o \u0148om spr\u00e1vy pod\u013ea usmernen\u00ed, ktor\u00e9 poskytuje Preferovan\u00e9 polo\u017eky pod\u00e1vania spr\u00e1v pre systematick\u00e9 preh\u013eady a metaanal\u00fdzy (PRISMA).<\/p>\n\n\n\n<p>Prim\u00e1rne v\u00fdsledn\u00e9 ukazovatele, ktor\u00e9 sa bud\u00fa bra\u0165 do \u00favahy, s\u00fa miera vypad\u00e1vania vlasov, miera odozvy na akupunkt\u00faru a op\u00e4tovn\u00fd rast vlasov. Rovnak\u00fdm sp\u00f4sobom, sekund\u00e1rne v\u00fdsledn\u00e9 opatrenia, ktor\u00e9 sa bud\u00fa bra\u0165 do \u00favahy, s\u00fa ne\u017eiaduce udalosti, kvalita \u017eivota a spokojnos\u0165 s v\u00fdskytom vlasov. V\u00fdskumn\u00e1 strat\u00e9gia bude obsahova\u0165 alopecia areata a akupunkt\u00faru ako hlavn\u00e9 k\u013e\u00fa\u010dov\u00e9 slov\u00e1.<\/p>\n\n\n\n<p>Pod\u013ea protokolu prijat\u00e9ho pre tento systematick\u00fd preh\u013ead pom\u00f4\u017ee vytvori\u0165 podrobn\u00fd s\u00fahrn zalo\u017een\u00fd na d\u00f4kazoch a \u00fa\u010dinnosti akupunkt\u00fary pri lie\u010dbe alopecia areata. Podrobne sa bud\u00fa diskutova\u0165 o r\u00f4znych probl\u00e9moch s\u00favisiacich s v\u00e4zbou lek\u00e1ra, bez inertnosti falo\u0161nej akupunkt\u00fary a akupunkt\u00fary ako komplexnej intervencie. Tento preh\u013ead pom\u00f4\u017ee lek\u00e1rom a pacientom v oblasti doplnkovej a tradi\u010dnej medic\u00edny.<\/p>\n\n\n\n<p><strong>Potenci\u00e1lne terapeutick\u00e9 aplik\u00e1cie v\u010delieho jedu pri ko\u017en\u00fdch chorob\u00e1ch a ich mechanizmoch: preh\u013ead literat\u00fary<\/strong><br>Na\u0161a ko\u017ea je najv\u00e4\u010d\u0161\u00edm org\u00e1nom n\u00e1\u0161ho tela. Ve\u013ek\u00fd vplyv na \u0148u maj\u00fa z\u00e1palov\u00e9, v\u00edrusov\u00e9 a bakteri\u00e1lne ochorenia, dokonca aj rakovina. Ko\u017en\u00e9 ochorenia ako psori\u00e1za, dermatit\u00edda, atopika a akn\u00e9 nie s\u00fa \u017eivot ohrozuj\u00face, ale nar\u00fa\u0161aj\u00fa norm\u00e1lny vzh\u013ead. Be\u017en\u00e9 lieky, ako s\u00fa antimikrobi\u00e1lne a kortikosteroidn\u00e9 lieky, sa be\u017ene pou\u017e\u00edvaj\u00fa na lie\u010dbu infek\u010dn\u00fdch a z\u00e1palov\u00fdch ko\u017en\u00fdch ochoren\u00ed.<\/p>\n\n\n\n<p>S t\u00fdmito terapiami je v\u0161ak spojen\u00fdch ve\u013ea ved\u013eaj\u0161\u00edch \u00fa\u010dinkov, najm\u00e4 ak sa pou\u017e\u00edvaj\u00fa dlhodobo. To je d\u00f4vod, pre\u010do teraz nieko\u013eko v\u00fdskumn\u00edkov h\u013ead\u00e1 alternat\u00edvne mo\u017enosti lie\u010dby na zvl\u00e1dnutie t\u00fdchto ko\u017en\u00fdch por\u00fach. Pr\u00edrodn\u00e9 zdroje sa sk\u00famaj\u00fa a vyhodnocuj\u00fa, aby sa minimalizovali ak\u00e9ko\u013evek ved\u013eaj\u0161ie \u00fa\u010dinky. V\u010del\u00ed jed je jednou z najlep\u0161\u00edch mo\u017enost\u00ed na vykon\u00e1vanie klinick\u00fdch \u0161t\u00fadi\u00ed. D\u00f4vodom je, \u017ee vykazuje protirakovinov\u00e9, antifung\u00e1lne, antiv\u00edrusov\u00e9, antibakteri\u00e1lne, antifibrotick\u00e9, antiapoptotick\u00e9 a protiz\u00e1palov\u00e9 vlastnosti.<\/p>\n\n\n\n<p>Lie\u010debn\u00e9 pou\u017eitie v\u010delieho jedu pri r\u00f4znych ko\u017en\u00fdch ochoreniach, ako je vitiligo, vr\u00e1sky, rany, psori\u00e1za, fotostarnutie, morfea, melan\u00f3m, atopick\u00e1 dermatit\u00edda, alop\u00e9cia a akn\u00e9, je potrebn\u00e9 d\u00f4kladne pre\u0161tudova\u0165.<br>V\u010del\u00ed jed, ktor\u00fd produkuj\u00fa v\u010dely medonosn\u00e9, patr\u00ed medzi zn\u00e1me pr\u00edrodn\u00e9 jedy. V\u010del\u00ed jed m\u00e1 jedine\u010dn\u00fd s\u00fabor chemik\u00e1li\u00ed, ako je lyzofosfolip\u00e1za, fosfomonoester\u00e1za, hyaluronid\u00e1za, fosfolip\u00e1za, MCD peptid, adolap\u00edn, apam\u00edn a melit\u00edn. Existuj\u00fa tie\u017e am\u00edny ako norepinefr\u00edn, dopam\u00edn a histam\u00edn. V\u010del\u00ed jed sa u\u017e dlho pou\u017e\u00edva ako \u00fa\u010dinn\u00e1 terapeutick\u00e1 l\u00e1tka. V niektor\u00fdch pr\u00edpadoch sa extrahovan\u00e1 a purifikovan\u00e1 forma v\u010delieho jedu pod\u00e1va injek\u010dnou strieka\u010dkou. Vo v\u0161eobecnosti sa v\u0161ak vstrekuje priamo v\u010del\u00edm bodnut\u00edm.<\/p>\n\n\n\n<p>Zistilo sa, \u017ee BV pom\u00e1ha pri potl\u00e1\u010dan\u00ed z\u00e1palu a zni\u017eovan\u00ed bolesti pri muskuloskelet\u00e1lnych poruch\u00e1ch, ako s\u00fa bedrov\u00e9 bolesti, reumatoidn\u00e1 artrit\u00edda a osteoartrit\u00edda. Pre svoje pozit\u00edvne terapeutick\u00e9 \u00fa\u010dinky sa v s\u00fa\u010dasnosti pou\u017e\u00edva aj na lie\u010dbu neurologick\u00fdch por\u00fach, ako s\u00fa: amyotrofick\u00e1 later\u00e1lna skler\u00f3za, Parkinsonova choroba a chronick\u00e1 neuralgia. Nieko\u013eko preh\u013eadov podporilo terapeutick\u00fa hodnotu v\u010delieho jedu, ale ani jeden sa nezameral na priamy \u00fa\u010dinok v\u010delieho jedu na r\u00f4zne ko\u017en\u00e9 ochorenia. Ale v tejto recenzii n\u00e1jdete zhrnutie aplik\u00e1cie v\u010delieho jedu pri alop\u00e9cii a jeho potenci\u00e1lneho terapeutick\u00e9ho mechanizmu.<\/p>\n\n\n\n<p>Na podporu presk\u00famania sa vykonala klinick\u00e1 \u0161t\u00fadia v dvoch r\u00f4znych kateg\u00f3ri\u00e1ch \u2013 \u0161t\u00fadia Vivo a \u0161t\u00fadia vitro. Terapeutick\u00e1 aplik\u00e1cia v\u010delieho jedu bola sk\u00faman\u00e1 pri r\u00f4znych ko\u017en\u00fdch ochoreniach: vitiligo, vr\u00e1sky, rany, psori\u00e1za, fotostarnutie, morfea, melan\u00f3m, atopick\u00e1 dermatit\u00edda, alop\u00e9cia a akn\u00e9. Hlavn\u00fdm \u00fa\u010delom tejto \u0161t\u00fadie je pom\u00f4c\u0165 v\u00fdskumn\u00edkom vypracova\u0165 spr\u00e1vnu n\u00e1sledn\u00fa \u0161t\u00fadiu na z\u00e1klade s\u00fa\u010dasn\u00fdch poznatkov t\u00fdkaj\u00facich sa klinick\u00fdch a experiment\u00e1lnych spr\u00e1v o v\u010delom jede. Tu sa bude diskutova\u0165 o alop\u00e9cii.<\/p>\n\n\n\n<p>Terapeutick\u00fd \u00fa\u010dinok v\u010delieho jedu pri alop\u00e9cii<br>Ma\u0165 zdrav\u00e9 vlasy hr\u00e1 d\u00f4le\u017eit\u00fa \u00falohu pri definovan\u00ed vzh\u013eadu \u010dloveka. Rovnak\u00fdm sp\u00f4sobom m\u00f4\u017ee vypad\u00e1vanie vlasov negat\u00edvne ovplyvni\u0165 sebavedomie a celkov\u00fd vzh\u013ead. Najzrejmej\u0161\u00edm d\u00f4vodom vypad\u00e1vania vlasov je genetick\u00e1 predispoz\u00edcia. Viacer\u00ed odborn\u00edci sa tie\u017e domnievaj\u00fa, \u017ee stres m\u00f4\u017ee vies\u0165 k vypad\u00e1vaniu vlasov u mlad\u00fdch mu\u017eov a \u017eien. Okrem genetickej predispoz\u00edcie a stresu m\u00f4\u017eu niektor\u00e9 choroby poko\u017eky hlavy vies\u0165 aj k vypad\u00e1vaniu vlasov. Ned\u00e1vna \u0161t\u00fadia potvrdila, \u017ee takmer 74 % subjektov vykazovalo pr\u00edznaky alop\u00e9cie v d\u00f4sledku z\u00e1palov\u00fdch por\u00fach, ako je kontakt a atopick\u00e1 dermatit\u00edda. A takmer 25,5 % pr\u00edpadov vykazovalo zn\u00e1mky nejak\u00e9ho druhu du\u0161evnej choroby.<\/p>\n\n\n\n<p>Pod\u013ea \u0161t\u00fadie Vivo<br>Prevent\u00edvne \u00fa\u010dinky v\u010delieho jedu na pacientov s alop\u00e9ciou sk\u00famali Part et al. klinick\u00e9 vy\u0161etrenie sa uskuto\u010dnilo pod\u00e1van\u00edm minoxidilu (2 %) alebo v\u010delieho jedu na dorz\u00e1lny povrch my\u0161\u00ed presne 19 dn\u00ed. Na vyvolanie katag\u00e9nu u my\u0161\u00ed sa pou\u017eil DEX (dexametaz\u00f3n).<\/p>\n\n\n\n<p>Zistilo sa, \u017ee v\u010del\u00ed jed mal za n\u00e1sledok rast vlasov u my\u0161\u00ed. Tento proces sa uskuto\u010dnil zv\u00fd\u0161en\u00edm KGF (keratinocytov\u00fd rastov\u00fd faktor), ktor\u00fd pom\u00e1ha stimulova\u0165 prolifer\u00e1ciu folikulov a zni\u017eova\u0165 5\u03b1-redukt\u00e1zu. Stalo sa to, \u017ee 5\u03b1-redukt\u00e1za pomohla enzymaticky katalyzova\u0165 transform\u00e1ciu testoster\u00f3nu na DHT, ktor\u00fd m\u00e1 vy\u0161\u0161iu afinitu vo\u010di androg\u00e9nnym receptorom. To nakoniec viedlo k vypad\u00e1vaniu vlasov, ke\u010f sa vlasov\u00e9 folikuly za\u010dali minimalizova\u0165.<\/p>\n\n\n\n<p>Je potrebn\u00e9 poznamena\u0165, \u017ee dutasterid a finasterid s\u00fa dve naj\u010dastej\u0161ie pou\u017e\u00edvan\u00e9 \u010dinidl\u00e1 na lie\u010dbu vypad\u00e1vania vlasov. Ke\u010f\u017ee s\u00fa zalo\u017een\u00e9 na ob\u0161trukcii 5\u03b1-redukt\u00e1zy, m\u00f4\u017eu vies\u0165 k z\u00e1va\u017en\u00fdm komplik\u00e1ci\u00e1m vr\u00e1tane gynekomastie, depresie a sexu\u00e1lnej dysfunkcie. V d\u00f4sledku toho sa lie\u010dba v jednom \u0161t\u00e1diu preru\u0161\u00ed.<\/p>\n\n\n\n<p>V tejto klinickej \u0161t\u00fadii nebola po podan\u00ed v\u010delieho jedu pozorovan\u00e1 \u017eiadna cytotoxicita, podr\u00e1\u017edenie, eryt\u00e9m a ed\u00e9m. Tak\u017ee v\u00fdsledky nazna\u010duj\u00fa, \u017ee v\u010del\u00ed jed mo\u017eno bezpe\u010dne pou\u017ei\u0165 na podporu rastu vlasov.<\/p>\n\n\n\n<p>Pod\u013ea Vitro Study<br>Celkov\u00e9 zdravie vlasov z\u00e1vis\u00ed od trvanie alebo cyklus anag\u00e9nnej f\u00e1zy. A kedyko\u013evek vlasy, ktor\u00e9 s\u00fa v telog\u00e9nnej, katag\u00e9nnej a anag\u00e9nnej f\u00e1ze, predstavuj\u00fa 9 %, 1 % a 90 %. Na uskuto\u010dnenie \u0161t\u00fadi\u00ed in vitro sa pou\u017eili bunky \u013eudskej derm\u00e1lnej papily stimulovan\u00e9 hDPC DEX, ktor\u00e9 uk\u00e1zali, \u017ee v\u010del\u00ed jed pom\u00e1ha regulova\u0165 rastov\u00e9 faktory, ktor\u00e9 zah\u0155\u0148aj\u00fa IGF-1, VEGF, FGF2 a FGF7. V\u010del\u00ed jed tie\u017e zvy\u0161uje prolifer\u00e1ciu hDPC, \u010do spolu s n\u00e1rastom rastov\u00fdch faktorov udr\u017euje vlasy v anag\u00e9nnom \u0161t\u00e1diu po dlh\u0161iu dobu.<br>Preto je v hDPC podporovan\u00fd rast vlasov.<\/p>\n\n\n\n<p>Bez ak\u00fdchko\u013evek pochybnost\u00ed m\u00e1 v\u010del\u00ed jed potenci\u00e1l prispie\u0165 k rastu vlasov. M\u00f4\u017ee sa akt\u00edvne pou\u017e\u00edva\u0165 na lie\u010dbu vypad\u00e1vania vlasov, preto\u017ee kontroluje progresiu katag\u00e9nnej f\u00e1zy a podporuje rastov\u00e9 faktory vlasov.<\/p>\n\n\n\n<p>Okrem alop\u00e9cie bolo vykonan\u00fdch nieko\u013eko \u0161t\u00fadi\u00ed na ur\u010denie \u00fa\u010dinku v\u010delieho jedu na r\u00f4zne ko\u017en\u00e9 ochorenia. Nakoniec neboli zaznamenan\u00e9 \u017eiadne v\u00e1\u017ene \u00fa\u010dinky. V\u010del\u00ed jed v\u0161ak nemo\u017eno pova\u017eova\u0165 za bezpe\u010dn\u00fd. Nako\u013eko m\u00f4\u017ee sp\u00f4sobi\u0165 anafylaxiu aj u t\u00fdch jedincov, ktor\u00ed mali negat\u00edvny ko\u017en\u00fd test na v\u010del\u00ed jed. Ke\u010f\u017ee anafylaxia sa m\u00f4\u017ee objavi\u0165 v akomko\u013evek stave, odpor\u00fa\u010da sa ma\u0165 ved\u013ea seba pohotovostn\u00fa s\u00fapravu na kontrolu jej sympt\u00f3mov.<\/p>\n\n\n\n<p>Je d\u00f4le\u017eit\u00e9 sledova\u0165 stav pacienta takmer 30 min\u00fat po podan\u00ed v\u010delieho jedu. Toto obdobie bolo ur\u010den\u00e9 na z\u00e1klade retrospekt\u00edvnej klinickej \u0161t\u00fadie, ktor\u00e1 nazna\u010dila, \u017ee medzi\u010das pre n\u00e1stup anafylaxie je presne 21,75 min\u00faty po injekcii lie\u010dby v\u010del\u00edm jedom. Za ur\u010dit\u00fdch podmienok m\u00f4\u017eu zv\u00fd\u0161en\u00e9 hladiny baz\u00e1lnej s\u00e9rovej trypt\u00e1zy tie\u017e vies\u0165 k v\u00fdskytu anafylaxie.<\/p>\n\n\n\n<p>Pod\u013ea tohto tvrdenia hr\u00e1 fyziologick\u00fd stav ka\u017ed\u00e9ho konkr\u00e9tneho organizmu pri pod\u00e1van\u00ed v\u010delieho jedu d\u00f4le\u017eit\u00fa \u00falohu pri ur\u010dovan\u00ed v\u00fdskytu anafylaxie. Anal\u00fdza \u00farovne bezpe\u010dnosti lie\u010dby v\u010del\u00edm jedom je rozhoduj\u00faca pre ur\u010denie vhodnej hodnoty v\u010delieho jedu potrebn\u00e9ho ako terapeutick\u00e9ho \u010dinidla. Je ve\u013emi n\u00e1dejn\u00e9, \u017ee v bud\u00facnosti sa uskuto\u010dnia rozsiahle klinick\u00e9 \u0161t\u00fadie, aby sa zabr\u00e1nilo v\u00fdskytu anafylaxie po podan\u00ed v\u010delieho jedu.<\/p>\n\n\n\n<p><strong>Zdroje:<a href=\"https:\/\/www.researchgate.net\/publication\/307655743_A_Case_of_Alopecia_Areata_Treated_with_Bee_Venom_and_Carthami_Flos_Herbal_Acupuncture\" target=\"_blank\" rel=\"noreferrer noopener\">\u200b<br>\u200bA Case of Alopecia Areata Treated with Bee Venom and Carthami Flos Herbal Acupuncture<\/a><\/strong>&nbsp;\u200b<br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27040904\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Bee Venom Promotes Hair Growth in Association with Inhibiting 5\u03b1-Reductase Expression<\/strong><\/a>&nbsp;\u200b&nbsp; &nbsp;&nbsp;<br><a href=\"https:\/\/cyberleninka.org\/article\/n\/883194\"><strong>Acupuncture for Treating Alopecia Areata: A Protocol of Systematic Review of Randomised Clinical Trials: Figure&nbsp;1<\/strong><\/a><br>\u200b<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6669657\/\"><strong>Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alopecia areata je org\u00e1novo \u0161pecifick\u00fd autoimunitn\u00fd proces, ktor\u00fd ni\u010d\u00ed vlasov\u00e9 folikuly. Presn\u00e9 pr\u00ed\u010diny v\u00fdskytu Alopecia areata st\u00e1le nie s\u00fa zn\u00e1me. Be\u017ene sa hovor\u00ed, \u017ee emocion\u00e1lny stres alebo ur\u010dit\u00e1 infekcia sp\u00fa\u0161\u0165a vypad\u00e1vanie vlasov. Zistilo sa, \u017ee postihuje najm\u00e4 \u013eud\u00ed, patriacich do vekovej kateg\u00f3rie medzi 20. a 50. rokom \u017eivota. Neexistuje \u017eiadna rodov\u00e1 diskrimin\u00e1cia ani zov\u0161eobec\u0148ovanie; m\u00f4\u017ee [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":94,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"ngg_post_thumbnail":0},"categories":[7],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lie\u010dba v\u010del\u00edm jedom pre ALOPECIA AREATA - apitoxin.sk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/apitoxin.sk\/2022\/07\/13\/liecba-vcelim-jedom-pre-alopecia-areata\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lie\u010dba v\u010del\u00edm jedom pre ALOPECIA AREATA - apitoxin.sk\" \/>\n<meta property=\"og:description\" content=\"Alopecia areata je org\u00e1novo \u0161pecifick\u00fd autoimunitn\u00fd proces, ktor\u00fd ni\u010d\u00ed vlasov\u00e9 folikuly. Presn\u00e9 pr\u00ed\u010diny v\u00fdskytu Alopecia areata st\u00e1le nie s\u00fa zn\u00e1me. Be\u017ene sa hovor\u00ed, \u017ee emocion\u00e1lny stres alebo ur\u010dit\u00e1 infekcia sp\u00fa\u0161\u0165a vypad\u00e1vanie vlasov. Zistilo sa, \u017ee postihuje najm\u00e4 \u013eud\u00ed, patriacich do vekovej kateg\u00f3rie medzi 20. a 50. rokom \u017eivota. 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